| With the rapid development of economy and material prosperity in the present so-ciety,the pursuit of a prosperous life has been leading to the quick pace of modern life.But the popular high-fat and high-calorie diet and the lack of long-term exercise due to heavy workload are easy to cause fat accumulation in the human body,and will further aggravate the accumulation of body fat,eventually leading to the formation of obesity.As one of the important issues that plagued human health,obesity is an important cause of hypertension,fatty liver,type II diabetes and other diseases.Therefore,con-trolling weight and keeping healthy life has been become one of the main goals of mod-ern people.Except strengthening exercise,most people choose to use some related drugs for better weight control.In terms of drug selection,most people tend to choose drugs derived from natural plants compared to synthetic drugs,and in terms of drug administration,drugs that enter the body through transdermal absorption in the form of essential oils,creams,or other cosmetics have higher bioavailability than oral drugs.However,in the actual operation there are some inevitable drawbacks,such as the short period of action of the drugs,the many times need for application and the inconvenience of application.In order to solve these problems,this paper selected water-soluble plant extracts as the core material,which was encapsulated with polyvinyl alcohol as microcapsules and then composited with polyester non-woven fabrics to fabricate the fabric patch ma-terial with sustained-release function.The material has a good drug release effect,and it can achieve the slow-release of drugs when combined with tight clothing,body sculpting underwear and other personal clothing,which can achieve the transdermal absorption of drugs of the human body during the wearing process.The main research content are shown as follows:1)In the study,polyvinyl alcohol slow-release microcapsules were prepared by interfacial polymerization.ACB celluplex was chosen as the core material,polyvinyl alcohol was chosen as the wall material,and glutaraldehyde was chosen as the cross-linking agent,and then the preparation process was optimized.The microcapsules pre-pared through the optimized preparation process have smooth surfaces and their particle size distributions are relatively uniform..These microcapsules also show good dispers-ibility under lightly ground conditions,and they have a particle size between 2.4?m and 14.5?m.The microcapsules can be stable under 240? condition,so that they can be used in finishing processes.The microencapsulation rates of microcapsules prepared under different reaction media range from 79.78%to 82.01%.What's more,these mi-crocapsules can release ACB celluplex when they are placed in wet environment,and they have a good storage stability in dry environment.The inhibition effects of lipase enzyme of microcapsules prepared under different reaction media have also been tested,using porcine pancreatic lipase activity was used as an indicator.The test results show that,microcapsules of each groups all have the inhibitory effect on the activity of por-cine pancreatic lipase,and the inhibition rates range from 15.61%to 31.33%,and the effect is related to its concentration.2)The Ultraviolet-visible spectroscopy analysis has been used to study the drug-loading rate,release behavior and release pattern of microcapsules prepared under dif-ferent reaction media conditions as the main means in this paper.The test results showed that,the microcapsules have obvious sustained-release effect of ACB celluplex when the drug loading rate of each group is during 37.41%to 39.03%,and the release process have little change when pH value changes from 4.22 to 7.54.The release pro-cesses of microcapsules prepaired in different media are all in according to the Korsmeyer-Peppas model and the release mechanism are judjed as a hybrid release mechanism composed of fick diffusion and skeleton dissolution.The maximum release duration of each groups ranges from 47.23 to 4336.42 hours.The correlation among the,the median particle size,the temperature of maximum decomposition rate and the maximum release time of the microcapsules are analysized at the level of significance of 0.1,using the mathematical analysis software SPSS.The results show that the vis-cosity of the reaction medium and the of regression analysis shows that a regression model of the reaction medium viscosity and the maximum release time of the micro-capsules have significant correlation.And their relationship can be established by a cubic function,and the model goodness of fit is 0.952,shows a good fitting goodness.The difference percentage between the measured value and the forecasting value is about 7.79%3)Ultraviolet-visible spectroscopy analysis,as a main characterization,was used to study the adsorption and fastness of ACB celluplex and commonly applied lining fabrics.Results showed that,polyester lining fabric has the lowest adsorption perfor-mance and fastness to theACB celluplex,so it is suitable for the drug-loaded composite fabric as a base fabric.And the composite structure of the microcapsule-hydrogel com-posite fabric has been designed based on the interaction between drugs and fabrics,then a 3 layers composite fabric was proposed.A water repellent fanished polyester nonwo-ven fabric is used as the water rej ect layer,and the calcium alginate-Polyvinyl alcohol/ACB celluplex microcapsule coating polyester nonwoven fabric is used as the drug-loaded layer,and these layers were adhered by Thermoplastic web.This fabric could meet the requirements that the drug utilization can be improved through the unidirec-tional transfer of moisture to the skin side,on the basis of ensuring the softness of the fabric.4)Four kinds of test characterization methods,namely,microscopic morphology analysis,air permeability test,moisture permeability test,and PhabrOmeter fabric eval-uation system have been used in this paper to study the preparation process of the drug-loaded composite fabric,and then the preparation process has been optimized through the morphology,hand feeling and air permeability and moisture permeability.The ef-fectiveness of the drug in the composite fabric has also been tested with the activity of porcine pancreas lipase taken as an indicator.The results of PhabrOmeter fabric evalu-ation system showed that,the difference of hand feeling of drug-loaded composite fab-ric before and after coating is small,and the coat fabric also can be used as a lining fabric,with light and soft features.Air permeability test results showed that the airper-meability rate of the microcapsule-hydrogel composite fabric prepaired in optimum process is 993.76,the reduction rate of is 18.49%.So it could be applied to people.The moisture permeability of the composite fabric is 143.82 g/(m2·h),the reduction ratio is 6.00%,which has a good resistance to moisture,and can realize one-way transmission of water to the skin.The resule of lipase activity inhibition effect tests show that the lipase activity improved with the improvement ofcoating thinkness and the addition of microcapsules.The drying methods have little affacts on the lipase activity inhibition rate of the composite fabric.5)The drug release behavior of the composite fabrics has been characterized by Ultraviolet-visible spectroscopy analysis,and the release behaviors and release patterns of polyvinyl alcohol microcapsules and calcium alginate hydrogels have been discussed.The test results showed that the release of ACB celluplex in the composite fabric fol-lows the Fick's law of diffusion and has a good sustained release effect.The cumulative release curve similarity factor test of drug-loaded fabrics and microcapsules showed that the cumulative release profile of drug-loaded composite fabrics is similar to the cumulative release profile of microcapsules,which can proof that the release pattern of the drug has not changed significantly.The inhibition rate of pancreatic lipase activity showed that the drug-loaded fabric has a certain inhibitory effect on pancreatic lipase activity and the inhibition rate was about 20.50%. |
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