Study On Preparation,Drug Loading And Controlled Release Properties Of Vanillin-Based Polymer Particles

Aldehyde containing polymer materials are widely used in the production and living of people.There are so many reports about how to introduce aldehyde group into molecule structure to prepare a variety of aldehyde containing polymer materials.However,the preparation of aldehyde containing polymer materials is very dependent on petroleum resources and their derivatives as raw materials.Therefore,it is of great social significance and economic value to develop new,green and renewable raw materials to replace petroleum resources and their derivatives to complete the preparation of some functional materials and chemicals.Vanillin is a kind of industrially produced lignin derivative.There are both aldehyde group and phenolic hydroxyl group in vanillin’s chemical structure,which provides a variety of possibilities for the development and preparation of vanillin-based aldehyde containing polymers.In this study,a kind of nanoscale polymer microsphere was prepared based on the vanillin and the application potential of this microsphere as drug carrier was explored.1、Vanillin methacrylate,a biological monomer,was successfully synthesized by esterification between vanillin and methacryloyl chloride.The influences of various factors on the comprehensive properties of the products were investigated respectively.Finally,polymer microspheres with nanoscale size(490nm),narrow size distribution(PDI=1.02)and strong swelling resistance were successfully prepared in the end.2、The prepared cross-linked polymer microspheres were used to conduct drug loading and drug release studies.We found that benzocaine could not be loaded onto microspheres and anisidine could be loaded on the microspheres successfully(465mg/g).Through a series of drug loading experiments with different initial concentrations and adsorption kinetics experiments,it was confirmed that the drug loading mechanism was Schiff base drug loading,and the drug loading behavior was related to the time of drug loading and the initial drug concentration.Through drug release experiments,we found that the microspheres showed different drug release behavior in different media.In summary,the microsphere has a strong amine drug loading capacity,and drug release behavior of the drug loaded microspheres showed obvious pH responsiveness.We think this kind of microspheres possess the potential as the amine drug carriers.