| In recent years,the data suggest that the incidence of colorectal cancer is increasing in China,and is also the leading cause of cancer deaths.In recent years,radical surgical treatment is one of the most effective methods for the treatment of colorectal cancer.Despite the use of adjuvant chemotherapy,there are still 40~50% of patients with stage II and III colorectal cancer recurrence and metastasis within 2 years after radical surgery.Our team of pre clinical work of international multi center cohort study showed that the Norway cohort after 1 years,2 years,3 years,4 years,5 years recurrence rate were 6.26%,11.95%,17.04%,20.45%,22.02%;China queue after 1 years,2 years,3 years,4 years,5 years the recurrence rates were 8.43%,17.39%,22.55%,25.49%,28.50%;the study confirmed that II,stage III disease 1 years Chinese medicine comprehensive treatment to reduce the relapse rate and the intervention function of traditional Chinese medicine,prescription effect could be a decisive role,the project to carry out the experience of 12 th Five-Year cohort study in the discussion.The purpose of this study is to analyze and summarize six Dihuang soup and Four Gentlemen Decoction intervention on II and III colorectal cancer syndromes evolution regularity,lay the foundation for the treatment system of combining traditional Chinese and Western medicine,this study uses retrospective and prospective analysis and information collection methods,discuss II and III colorectal cancer patients with TCM syndrome type the distribution and dynamic evolution of the law,is to provide a theoretical basis for the treatment of traditional Chinese medicine II,II colorectal cancer treatment.Clinical Study I: A prospective cohort study of Decoction of Four Mild Drugs and decoction of Six Ingredient Rehmannia Decoction in reducing the recurrence and metastasis of II and III colorectal cancerObjective: Decoction of Four Mild Drugs and decoction of Six Ingredient Rehmanni a Decoction of TCM Comprehensive treatment scheme to reduce audit prospective cohort study of recurrence rate,metastasis of II III colorectal cancer after operation,discover the existing problems in the process of research and to be corrected,so as to promote the project progress and improve the quality of research.Methodology: Methods a prospective cohort study using the 200 cases from August 2014 to September 2016 in China Chinese Academy of Sciences,Xiyuan Hospital and Peking University cancer hospital were divided into two groups,focus on monitoring the cases into groups and the case report forms,according to whether the traditional Chinese medicine and Western medicine combined with traditional Chinese medicine and Western medicine for the queue queue,the general information of the patients of two columns,medical and living habits,pathological data,genotyping and metastasis were related research.Results:(1)the first patient in the center of Xiyuan was admitted to the group in August 20,2014 as the last of the 1 patients in the group was admitted to the hospital in August 14,2016.A total of 100 patients were enrolled in the study,of which 5 were excluded from the study.95 patients were treated with traditional Chinese medic ine.The first hospital of Peking University tumor patients in time for the February 16,2015,the last 1 patients in time for the August 3,2016,completed a total of 100 patients were enrolled,including 4 cases of non-compliance with the study protocol to be removed,of which 18 cases received traditional Chinese medicine treatment of 78 cases of patients received pure western medicine treatment.(2)two columns have no significant differences in age,gender,medical history and living habits.(P is greater than 0.05)(3)listed in the two syndromes(deficiency of spleen and kidney deficiency,spleen and kidney deficiency syndrome two,other)showed no significant difference.(4)the recurrence and metastasis: integrative treatment cohort 1 years incidence of recurrence and metastasis in 5 cases,the 1 year recurrence rate was 4.42%,2 years,recurrence and metastasis of 8 cases,the 2 year recurrence rate was 7.08%;the western medicine cohort occurred within 1 years of recurrence and metastasis of 3 cases with 2 years there were 3 cases of recurrence,metastasis and recurrence rate of 1 years,2 years was 3.85%.Conclusion: The researchers tried and explored in the 12 th Five-Year issue of the nation.Patient compliance is one of the main factors affecting the progress of the group,compliance with the experts of their trust is higher than the lower average doctor,follow-up time,reduce the lost is an important work in the group after the completion of the effective coordination and communication between groups to research the information balance,timely record the treatment process patients are key measures to improve the quality of research.Regular monitoring to ensure the progress and quality of the project,the formation of effective coordination and communication mechanism.It takes a long time for each patient to enter the group,follow up and fill in the form.The researchers need to devote a lot of time and energy to finish the task within the prescribed time.Four gentlemen and the decoction of six ingredients in the clinical application of a wide range of basic,and pharmacology and animal studies have shown that tumor suppression effect.Because of the obvious difference between the two centers in the first group,there were fewer cases of metastasis and recurrence of the target cases,this study needs more long-term follow-up observations to draw accurate conclusions.Clinical StudyII:Study on the dynamic evolution law of II,III stage colorectal cancerObjective:Objective to investigate the distribution and dynamic evolution of TCM syndromes in patients with II and III colorectal cancer,and to provide scientific evidence for the prevention and treatment of Chinese medicine.Methodology: The retrospective and prospective study method,collected 123 cases of II and III stage of colorectal cancer were 3,2 and 1 in prevalence,prevalence,chemotherapy,clinical symptoms of TCM data every 6 months after the operation stage,the use of EXECL to establish a database,analyze the frequency statistics,clustering by R the statistical software,the results change at different stages of the syndrome distribution regularity and dynamicResults: II,III colorectal cancer surgery 3 years ago to the prevalence period spleen deficiency increased gradually,and the symptoms of abdominal distension,diarrhea,hematochezia main symptoms increased,postoperative chemotherapy of spleen and kidney syndrome type two viscera high to 3 years after surgery decreased gradually during chemotherapy mainly nocturia,Shenpi lazy words,food less is the waist and leg soft symptoms to 3 years after surgery to alleviate symptoms gradually trend.To study the early stage of II and III colorectal cancer patients,the distribution and dynamic evolution law of the late stage of the disease can provide an objective basis for the establishment of the traditional Chinese medicine treatment.Conclusion: II and III colon cancer patients for TCM Syndromes of deficiency and deficiency,which can be manifested as spleen,kidney,liver,lung function and Zang Fu deficiency: the empirical manifestation of qi stagnation,blood stasis and phlegm stasis and toxin.The symptoms of spleen deficiency in patients with chemotherapy before operation were higher,and the symptoms of deficiency of spleen and kidney were high during the period of chemotherapy.Two years later,the intervention of Chinese medicine treatment gradually reduced the original syndrome after the operation for the last 3 years.Pressure... |
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