| PURPOSE:The use of modern means of science and technology dataminingto explore the clinical application of Chinese medicine master diaphoretics(containing Radix Bupleuri,ramulus cinnamomi,Radix Saposhnikoviae,radix puerariae,asarum)dose and related laws,and provide objective basis for the new version of "China Pharmacopoeia" revision and perfection for the safe and effective and rational use of medicine to provide support guidance.It provides a scientific and effective method for the study of clinical and experimental medicine compatibility laws.METHOD:The adult oral Decoction daily as the core collection of Chinese medicine master published medical records,medical case database,containing jiebiao drugs extracted from(Radix Bupleuri,cinnamomi,Radix Saposhnikoviae,radix puerariae,asarum)prescription as the data set,using SPSS Modeler 17 software,using Apriori algorithm,mining dosage,compatibility rule and association with diseases;core drug dose ratio,compatibility rule and association with diseases;drug dose and 2015 version of "Chinese Pharmacopoeia" comparative study etc..And through the mesh diagram(Web),histogram,bar graph,such as graphic display.RESULT:1.Chinese medicine master application of Radix Bupleuri,ramulus cinnamomi,parsnip,kudzu,asarum dose does not comply with the "Pharmacopoeia" provisions Chinese dose of 17.21% to 52.48%,suggesting that Chinese medicine master of clinical dosage is too high,"Chinese Pharmacopoeia" provisions of the narrow range of doses.2.Dose threshold 2g~75g,commonly used dose range of 3g~5g.High frequency disease treatment window: the treatment of menstrual disease for 2g~20g;treatment of hypochondriac pain is 3g~25g;treatment of cold is3 g~24g;treatment of stomach pain is 4.5g~20g.Often with the tonic medicine,activating blood circulation and removing blood stasis drugs,regulating qi drugs,heat clearing drugs,expectorant drugs,diaphoretics and diuretic dampness excreting drugs for treatment of menstrual disease,hypochondriac pain,cold,stomach pain.When the support is greater than 10%,the confidence is not less than 60%,obtained 51 drug combination group,confidence =1,produced a total of 38 rules.The core drugs are Bupleurum chinense,Radix Angelicae sinensis,Poria cocos,Radix Bupleuri,Radix Paeoniae Alba,Radix Bupleuri and Glycyrrhiza uralensis fisch.Among them,bupleurum-licorice is commonly used in the treatment of menstrual disease,pain,etc.;Bupleurum-Angelica is commonly used in menstrual diseases,such as pain,etc.Bupleurum Fuling is commonly used in menstrual disease,hypochondriac pain,etc.3.Ramulus Cinnamomi dose threshold 1.2g~50g,commonly used dose range 4.5g~15g.High frequency treatment window: arthromyodynia 3g~15g,palpitations 3g~24g,chest pain2.4g~24g,dyspnea3g~15g,menstrual disease3g~15g.Often with tonic medicine,blood stasis,diaphoretic,dampness,regulating qi,dampness and heat drugs,warming medicine,astringent drug,apophlegmatisant different categories for treatment of arthralgia,palpitation,chest pain,dyspnea and menstrual disease.When the support is greater than 10%,confidence is more than 60%,get 37 drug combination group,confidence =1,generated 32 rules.The core for drug-Ramulus Cinnamomi,Poria Cocos,licorice.Ramulus Cinnamomi and Radix Paeoniae Alba.Among them,Ramulus Cinnamomi,Poria Cocos-commonly used in the treatment of palpitation,edema;Ramulus Cinnamomi-licorice is commonly used in the attack,such as colds;Ramulus Cinnamomi-licoricecommonly used in palpitation,arthralgia;Ramulus Cinnamomi-Radix Paeoniae Alba is commonly used in the attack,menstrual disease etc..4.Saposhnikovia Divaricatathreshold 2.4g~30g,the usual dose range of 6g~15g.High frequency treatment window: arthromyodynia 3g~15g,cold urticaria6g~20g,cold 3g~15g,diarrhea5g~15g.With the tonic medicine,relieving drugs,antipyretic,diuresis medicine,medicine for rheumatism,expectorantsand antispasmodic,dampness,blood stasis and Qi regulating drugs such as different types of combined treatment of arthralgia syndrome,urticaria,colds,diarrhea.When the support is greater than 10%,the confidence is not less than 60%,obtained 44 drug combination group,confidence =1,produced a total of 38 rules.Core drugs for the Saposhnikovia Divaricata-licorice,Saposhnikovia Divaricata-Angelica,Saposhnikovia Divaricata-Astragalus,Saposhnikovia Divaricata-white peony,Saposhnikovia Divaricata-Atractylodes macrocephala.The Saposhnikovia Divaricata-licorice is commonly used in the treatment of arthralgia syndrome,such as the cold;Saposhnikovia Divaricata-Atractylodes commonly used in diarrhea,urticaria;Saposhnikovia Divaricata-commonly used in arthromyodynia.5.Puerarin dose threshold 3g~40g,commonly used dose range 9g~30g.High frequency treatment window: the treatment of obstruction of 9g~30g;the treatment of vertigo 6g~30g the treatment of stroke of 9g~30g;treatment of arthralgia syndrome 10g~ 40 g.With the tonic,antipyretic,blood stasis,relieving drugs,diuretics for eliminating dampness,antispasmodic,resuscitation medicine,Qi medicine and drug digestion different categories such as compatibility,treatment of chest pain,dizziness,stroke,arthralgia.When the support is greater than 10%,the confidence is not less than 30%,have used a combination of drugs in 42 groups,confidence =1,produced a total of 36 rules.The core drugs were Radix Puerariae Rhizoma Chuanxiong,Radix Puerariae Radix Salviae Miltiorrhizae,Radix Puerariae Radix glycyrrhizae.Among them,Radix Chuanxiong commonly used in the treatment of chest pain and stroke;Radix Salvia is commonly used in the chest,vertigo;Pueraria-licorice is commonly used in cold,headache,etc.6.Asarum dose threshold 0.3g~15g,commonly used dose range 3g~6g.High frequency disease treatment window: treatment of headache was 1.5g~15g;2 g~9g for treatment of arthralgia syndrome;treatment of asthma is 1.5g~12g;the treatment of cough is 2g~12g.With the diaphoretic,tonic medicine,blood stasis,heat clearing drugs,warm in medicine,antispasmodic,phlegm medicine,dampness medicine,astringent drugs and medicine for relieving cough and asthma and other different types of combinations,for the treatment of headache,arthralgia,dyspnea,cough.When the support is greater than 10%,the confidence is not less than 60%,the 43 drug combination group,confidence =1,produced a total of 43 rules.The core drugs were Asarum-Angelica,asarum chuanxiong,asarum-Glycyrrhiza uralensis,asarum-Ramulus cinnamomi.Among them,Chinese angelica Asarum-commonly used in the treatment of arthralgia,headache;Asarum Chuanxiong commonly used in headache,arthralgia;Asarum-licorice commonly used in headache,cough;Guizhi Asarum-commonly used in asthma attack,etc..CONCLUSION:The clinical application of Chinese medicine master diaphoretics(containing Radix Bupleuri,ramulus cinnamomi,Radix Saposhnikoviae,radix puerariae,asarum)dosage is too high,"Chinese Pharmacopoeia" provisions of the narrow range of doses;The five drugs had a wide range of dose thresholds,and can play a therapeutic role;The five drugs have different therapeutic windows for different diseases and syndromes.The same drug and different therapeutic window may have different therapeutic effects on different disease syndromes;The clinical compatibility and adaptation of the five drugs are quite extensive;The dose ratio between the five core drugs reveals that the national master of medicine not only pays attention to the effective combination between drugs,but also pays more attention to the dose ratio between the combination drugs.These concepts and experience have important theoretical value and practical significance,and will have a far-reaching impact on clinical medication. |
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