Relationship Between Family Cancer History And Breast Cancer And SNP Research Review

Objective The first part:Analyse the clinical and pathological characteristics breast cancer patients with family history or not to summarize characteristics of breast cancer cases with different family history. The second part:Collect literature about breast cancer related single nucleotide polymorphism (SNP) to find clues for further genetic and genome studies. SNP loci in BRCA1, BRCA2 gene.Method In first part of the study,356 cases of breast cancer from Hubei Province were collected from electronic medical records and medical records department of Wuhan University Renmin Hospital.Clinical and pathological data of the patients were classified and SPSS statistical software was used to complete statistical analysis. In second part literature about breast cancer related SNP research were collected and summarized.Results In first part of the study a total of 356cases of breast cancer were analysed, including 284 cases without family cancer history,72 cases with family history of breast cancer or other tumors,11 cases with breast cancer family history and 61 cases with family history of other tumors. In 356 cases, patients with only one first degree relative having breast cancer accounted for 9.0%, those with only one second degree relative having breast cancer accounted for 2.0%, those with two or more relatives having breast cancer accounted for 0.0%. The proportion of patients having two or more relatives suffering from other cancer was 4.0%,16% had only one first degree relative suffering from other cancer. In total, proportion of breast cancer diagnosis≤ 45 years old was 69.9%,>45 years old was 30.1%. Menarche age of the patients under 12 years old accounted for 10.4%, menarche age>12 years of age accounted for 87.1%. There are 51.4% premenopausal patients,46.9% patients with menopause. Non multifocal disease accounted for 91.9%, multifocal disease accounted for 8.1%. The proportion of patients with 0～1 children 55.9%,37.9% had more than 2 children. Tumor>2cm accounted for 45.8%, less than 2cm accounted for 40.2%. Invasive ductal carcinoma grade Ⅰ～Ⅱ accounted for 36.0%, Ⅲ accounted for 38.8%, non invasive ductal carcinoma accounted for 24.7%. Ductal carcinoma of the proportion of 93.5%, the proportion of other cancer 6.5%. Luminal A subtype was 31.5%, Luminal B subtype the proportion of 38.8%, the proportion of type 43.8%, Her-2 type proportion 12.1%, triple negative 9.8%.86.2% modified radical mastectomy, breast conserving surgery 5.3%, simple excision 2.5%, local resection in 1.7%, biopsy or no surgery proportion was 4.2%. No lymph node metastasis 44.9%,1-3 accounted for 19.1%,4-9 accounted for 16.9%,>9 accounted for 9.8%. Between patients with or without family cancer history, molecular subtype was different, and the difference was statistically significant (P<0.05). Age, age of menarche, menopose, the number of children,multifocal disease or not, tumor size, pathological type and grade, operation mode and lymph nodes of metastasis were not different (P>0.05). Comparison between two groups were carried out. And the testing statistical level was adjusted. Data showed that proportion of breast cancer cases with family cancer history in Her-2 subtype was higher than proportion of breast cancer cases with family cancer history in Luminal A subtype, the difference was statistically significant (P=0.000<0.005). Proportion of breast cancer cases with family cancer history in Her-2 subtype was higher than proportion of breast cancer cases with family cancer history in Luminal B subtype, the difference was statistically significant (P=0.003<0.005). Proportion of breast cancer cases with family cancer history in triple negative subtype was higher than proportion of breast cancer cases with family cancer history in Luminal A subtype, the difference was statistically significant (P=0.000<0.005). Differences between other molecular subtypes were not observed (P>0.005).Among breast cancer cases with family breast cancer history, or other cancer family history or not any family cancer history, molecular subtype was different, and the difference was statistically significant (P<0.05), age, age of menarche, menopose, the number of children,multifocal disease or not, tumor size, pathological type and grade, operation mode and lymph nodes of metastasis were not different (P>0.05). Comparison between two groups were carried out. And the testing statistical level was adjusted. Data showed that proportion of breast cancer cases with other family cancer history in Her-2 subtype was higher than the proportion of breast cancer cases with other family cancer history in Luminal A subtype, the difference was statistically significant (P=0.000<0.002). Differences between other molecular subtypes were not observed (P>0.002). The second part research reviewed main literature in this field, and made summary. It was found that Chinese population has distinct SNPs which were related to breast cancer in different clinical stages.Conclusion In Hubei Province, family cancer history is related to breast cancer molecular subtype. HER2 and triple negative subtype breast cancer has higher proportion of family cancer history, whereas Luminal A or Luminal B subtype has lower proportion of family cancer history. HER2 subtype breast cancer patients have higher proportion of other family cancer history, while Luminal A subtype patients have lower proportion of other family cancer history. Among the SNP sites in BRCA1 and BRCA2 gene, DNA repair genes and genes related to tumor growth an metastasis, distinct SNPs could be included in breast cancer screening to assess breast cancer risk of Chinese women.