Clinical Research On Prescription Of Tangzhiqing To Interfere In The Syndrome Of Deficiency Of Both Qi And Yin With Phlegm And Blood Stasis In Impaired Glucose Tolerance Combined With Dyslipidemia

Purpose:To discuss the understanding of traditional Chinese medicine about impaired glucose tolarence combined with dyslipidemia by using prescription of tangzhiqing. To observe the therapeutic efficacy of this method in treating the syndrome of deficiency of both Qi and Yin with phlegm and blood stasis of impaired glucose tolarence combined with dyslipidemia and to investigate the mechanism of this method.Methods:A randomized, controlled trial was conducted.60patients with the syndrome of deficiency of both Qi and Yin with phlegm and blood stasis of impaired glucose tolarence combined with dyslipidemia were randomly classified into two groups. Besides the intervention of living behavior and western medicine, the patients of the treatment group (n=30) were treated by Chinese medicine while the patients of control group (n=30) were not. Three months was a course of treatment. The observed indexes included both change in the clinical symptoms and signs, FBG, PBG, HbAlC, weight, BMI, WC, HC, WHR, FINS, IAI, blood-fat and safety indexes. All data were analyzed by the SPSS15.0statistics software.Results:Before treatment, the gender, age, course of disease of the two groups had no differeces.①Both the treatment group and control group have significant difference on curative effect score between before and after treatment and the two groups. The total curative effect of treatment group was93.33%while total curative effect of control group was50,00%. The treatment group gained an advantage over the control group (P<0.01).②The weight, BMI of both groups and the WC, WHR of treatment group were decreased, compared with pre-treatment there is statistically significant (P<0.01). The WC, HC, WHR of control group and the HC of treatment group were not decreased after treatment(P>0.05). The descent of BMI, WC, WHR in treatment group had a statistically significant compared with control group(P<0.05). The treatment group had an advantage over the control group in weight(P<0.01).③The FBG, PBG, HbAlC of the two groups were decreased, compared with pre-treatment there is statistically significant (P<0.01). The total curative effect of treatment group is93.33%, which of control group is50.00%. And the treatment group had an advantage over the control group(P<0.01).④The FINS of the treatment group were decreased, the IAI were elevated, compared with pre-treatment there is statistically significant (P<0.01). The IAI of control group were elevated, compared with pre-treatment there is statistically significant (p<0.05) while the FINS didn’t (P>0.05). And the treatment group had an advantage over the control group(P<0.01).⑤The TG, TC, LDL-C of the two groups were decreased, the HDL-C of them were elevated, compared with pre-treatment there is a remarkable statistically significant (P<0.01). And the treatment group had an advantage over the control group in TG, TC, HDL-C(P<0.01). The curative effect of blood fat in treatment group reached93.33%, which was33.33%in control group. The curative effect of treatment group was better than that of control group(p<0.01).⑥Safety indicators: Liver and kidney function tests were in the normal range. Both groups were no severe adverse reactions.Conclusion:From the preliminary clinical research, the prescription of tangzhiqing can not only improve the clinical symptoms and insulin sensitivity, but also can reduce weight, blood glucose, lipid. It is safe and effective has a broad prospect of application. It is worth studying deeply and developing further.