The Theory And Experimental Research On Treating Arteriosclerosis Obliterans Form "Heart" On The Basis Of "Heart Dominating Blood And Vessels"

Objective: The research proposed that arteriosclerosis obliterans (ASO) might betreated from the aspect of "heart" on the basis of theory of "heart governing blood andvessels". How the decoction of Yangxintongmai Decoction acts on the type of qi deficiencyand blood stasis ASO rabit is to be observed. The conclusion may provide scientific basisand effective prescription for ASO from the main theory of the "heart" in clinic andscientific evidence for "heart governing blood and vessels" as well.Method:(1) Theoretical research: A literature review on “heart governs the blood andvessels” was applied to exploring the scientific and feasibility of treating ASO form“heart” on the basis of elucidating relationship among “heart”,“blood”, and “vessels”and the physiology and pathology of "heart governing blood and vessels"."Heartgoverning blood and vessels” was interpreted through studying ASO pathogenesis and therelation between ASO and heart.(2) Experimental research: Yangxintongmai Decoctionwas selected to see its action and mechanism on ASO rabbit by light electron microscope,immunohistochemistry, radio-immunology, enzyme linked immunoassay because thedecoction was supposed to reinforce heart qi, nourish blood and protect circulation. Theconclusion may provide scientific evidence and effective prescription for ASO from themain theory of the "heart governing blood and vessels" in clinic.Results:(1) Theoretical research: the research holds that the lesion of ASO is vesselwhile the pathogenesis of ASO is rooted from the heart and therefore can be treated fromheart. The level of BNP secreted form the heart in ASO was increased and it would reduceET-1and VSMC. We conjecture that BNP secreted from the heart is one of material base of"heart governs the blood and vessels".(2) Experimental research: Yangxintongmai Decoction can change hyperplasia of vscular endothelial cells and VSMC. It can decreaseproliferation percent of VSMC and the content of TC, TG, LDL, ET-1, BNP, Hs-CRP inASO rabbit. It can increase the content of HDL, NO in ASO rabbit.Conclusions: Yangxintongmai Decoction can treat ASO by regulating vscularendothelial cells, inhibiting VSMC, anti-inflammatory and reducing lipid. It providescientific evidence and effective prescription for treating ASO from the main theory of the"heart". BNP secreted from the heart is one of the matter for “heart governing blood andvessels”. It provides scientific basis for interpreting "heart governing blood and vessels".