Comparison Of Neural Stem Cells And Bone Marrow Mesenchymal Stem Cells Transplantation For Spinal Cord Injury

Object:Compare the Curative Effect of Transplantation Between the Nscs and Bmscs for Spinal Cord Injury. Method:Spinal Cord Semi-Intersection Wistar Rat Model Were Established and Were Randomly Divided into Group Of BMSC Injected (N=10), Nscs Injected (N=10), the PBS Injected (N=10) and Sham Operation Group of Only the Lamina Opened (N=10). After the Transplantation, the BBB Locomotor Function Scores, Immunohistochemistry and Magnetic Resonance Imaging of Position Half Cut Were Administered. Results:Scores of BBB of Nscs Injected Group Was Significantly Higher than Bmscs Injected Group, Scores of BBB of Nscs Injected Group and Bmscs Injected Group Were Significantly Higher than the PBS Injected Group. Labeled Nscs and Bmscs Can Be Observed in Slices of Half Cut Part of Spinal Cord, The MRI Resonance Imaging Show That After Transplantation Syringomyelia Has Been Reduced. Conclusion:Intravenous Injection of Nscs, Bmscs Can Improve the Motor Function of Spinal Cord Injury in Rats, but the Effect of Injection of Nscs Was Better. After the Intravenous Injection of Stem Cells, the Cells Can Migrate to the Location of the Spinal Cord Injury, Magnetic Resonance Imaging Showed Syringomyelia Has Been Reduced, Suggesting That Stem Cells May Supplement or Replace Lost Nerve Cells, Repair the Deficient Neural Organization and the Functional Neural Units and Rebuild Nerve Loops.