The Study Of The Contemporary Chinese Herbal Treatment Of Eczema Which Based On Data Mining

PURPOSEDisease-syndrome Integration is the major medical model of chinese medicine. Pathogenesis revealed by Syndrome is the key process in Holistic Diagnosis and Treatment. Clarifying the basic characteristics of the pathogenesis of eczema and its theories, therapeutic principles, formulae and herbal medicines, would be able to effectively improve efficacy. Literature study found that viewpoints of both ancient and modern doctors were basically the same, of which mainly in the Blood status, Lung, Spleen and Kidney were related mostly to eczema, followed by heart and liver. But there are some discrepancies in symptom descriptions, controversies in therapeutic principle and preferences in prescriptions. Therefore, effective eczema prescription of experienced doctors are collected in this article. FP-Growth Association Rule Analysis was undergone in order to discover new knowledge, reveal effective herbal prescription, such that a step forward in clinical and research field could be made.METHODSRetrieving published in February 1988-November 2014 in China National Knowledge about the TCM medical case of eczema, and based on inclusion and exclusion criteria, to build Chinese medicine eczema medical records database; performing data mining, statistical analysis before, in advance of the original medical records Data were standardized drug names, typos corrected, standardized medical terminology, to find the original data preprocessing methods; then standard selected a total of 354 medical records of TCM diagnosis of acne times, the use of public consultations Medcase V3.2 warehouse membership MEDICA vein pattern data recording mining system, the establishment of medical case collection, storage database, and a database of medical records income data were standardized and multiple data entry cleanup. Glossary of terms in the specification symptoms altogether 87,1040 the cumulative frequency specification premise, build sets collection, storage, collation, analysis, digging in one of the medical case data from multiple data mining methods and modules mining platform; through Medcase V3.2 system, using data mining operation to strengthen the association rule model, Medcase Record Mining System, Association Rule Analysis platform, Xminer Operation Tool computing tools and strengthen the FP-Growth algorithm, based on statistical analysis of the results from the tongue, pulse, therapy, prescription medication and other aspects of traditional Chinese medicine with traditional Chinese medicine theory eczema Medical Records experience summary.RESULTSFor frequency analysis, the high frequency of clinical symptoms doctors treat eczema contemporary medical case appears mainly itching, then dry, insomnia, irritability and dry mouth; followed by oozing lesions, papules, erythema, crusting, erosion and scratches; lesions followed by the body, head, face, limbs, torso. High frequency tongue conditions were red tongue, pink tongue, thin white fur, yellow greasy moss, pale yellow fur, fur, white and greasy fur. High-frequency pulse terms were smooth pulse(滑),rapid(数),thin(细),taut(弦),deep(沉),weak(弱),floating(浮),slow(缓),soggy(濡),purple index-finger vein(指纹紫),purple index-finger vein with stagnationi滞纹紫滞),Iarge(大),normal(平),tiny(微),deep index-finger vein with stagnation(指纹沉滞),dark red index-finger vein (指纹赤),purple and red index-finger vein指纹紫红), hollow(虚),ale purple index-finger vein pale purple(指纹淡紫),arrhythmia(结),red index-finger vein (指纹红),index-finger vein green(指纹�'),index-finger vein bruising(指纹�'紫).High-frequency therapeutic principles occurred in the medical records included mainly clearing away heat(清热),termination of itching(止�')、dispering wind(祛风)、spleen strengthening(健脾)、remove wetness(除湿)、induce diuresis(利湿)、detoxicating (解�')、nourishing blood(养血)、cooling blood(凉血)、dredging wind (疏风)、drying wetness(:燥湿)、activating blood(活血)、warm yang(温阳)、eliminate wet(祛湿)、dispersing cold (润燥)、dampness percolating(渗湿)、enhancing qi(益气)、dispersing cold (散�')、evaporate wetness(化湿)and nourishing blood(养阴).After integration and standardization, the above-mentioned therapeutic principles were basically aligned with the textbook of Zhong Yi Wai Ke Xue, written by D.M. LU, published by Shanghai Scientific and Technical Publishers, explained that cleaning away heat(清热),induce diuresis (利湿)、nourrishing blood(养血)、dispersing wind(祛风)、spleen strengthening(健脾)、dredging wind(疏风)were the main therapeutic principles. The research found that flexible therapeutic principles were applied by the contemporary practitioners to cope with complicated situation in treating eczema.High-frequency herbal medicines occurred in the medical records were mainly Dictamni Radicis Cortex(白鲜皮),Dictamni Radicis Cortex(甘草),Radix Saposhnikoviae divaricatae(防风),tractylodes Lancea(苍术),Poria cocos(Schw.)Wolf(茯苓),Coix lacryma-jobi L. var. ma-guen (Roman) Stapf(薏苡仁),Kochiae(地肤子),Radix Rehmanniae(生地),Moutan Radicis Cortex(丹皮),Radix Angelicae sinensis(当�'),Phelloendron amurense Rupr. Cryptotympana pustulata Fabricius(蝉蜕),Atractylodes macrocephala Koidz.High frequency herbal medicine could be categorized in blood-cooling medicine(凉血药),blood-activating medicine(活血药),heat-clearing detoxicating medicine (清热解�'药),heat-clearing dampness-drying medicine(清热燥湿药),according to the classification in the textbook of Chinese Material Medica written by Z.Q. LEI, published by Shanghai Scientific and Technical Publishers.High frequency herbal medicine could be categorized in several types, namely heat-clearing dampness-drying medicine(清热燥湿药),relieving exterior syndrome medicine(解表药),inducing diuresis medicine(利水渗湿药),diuretic medicine(利尿通淋药),heat-clearing and blood-cooling medicine (清热凉血药),nourishing blood medicine(补血药),heat-clearing detoxicating medicine (清热解�'药),spleen-tonifying dampness-percolating medicine(健脾渗湿),according to the classification mentioned in the textbook of Chinese Material Medica written by Z.Q. LEI, published by Shanghai Scientific and Technical Publishers.In the Medicine Internal Association Rule, there are 12 pairing use like 1. Dictamni Radicis Cortex.(白鲜皮)、Kochia scoparia(L.)Schrad(地肤子)；2.Dictamni Radicis Cortex.(白鲜皮)、Sophora flavescen Ait(苦参)；3. Dictamni Radicis Cortex.(白鲜皮)、Radix Glycyrrhizae Uralensisl[甘草)；4. Dictamni Radicis Cortex.(白鲜皮)、Saposhnikovia divaricata (Turez.) Schischk.(防风)；5.Dictamni Radicis Cortex.(白鲜皮)、Rehmannia glutinosa Libosch(生地);6. Dictamni Radicis Cortex.(白鲜皮)、Coix lacryma-jobi L. var. ma-guen (Roman) Stapf(慧苡仁)；7. Dictamni Radicis Cortex.(白鲜皮)、Atractylodes lancea Thunb.DC(苍术)；8. Dictamni Radicis Cortex.((白鲜皮)、Poria cocos (Schw.) Wolf((茯苓)；9. Radix Glycyrrhizae Uralensis(甘草)、Rehmannia glutinosa Libosch(生地)；10. Rehmannia glutinosa Libosch(生地)、Paeonia suffruticosa Andr.(丹皮);11. Atractylodes lancea (Thunb.) DC(苍术)、Phelloendron amurense Rupr.(黄柏);12. Atractylodes lancea (Thunb.) DC(苍术)、Saposhnikovia divaricata (Turez.) Schischk.(防风);13. Atractylodes lancea (Thunb. DC(苍术)、Coix lacryma-jobi L. var. ma-guen (Roman) Stapf(薏苡仁);14. Saposhnikovia divaricata (Turez.) Schischk.(防风)、Radix Glycyrrhizae Uralensis(甘草)；15.Saposhnikovia divaricata (Turez.) Schischk.((防风)、Kochia scoparia(L.)Schrad(地肤子).CONCLUSIONBy performing statistical analysis and association rule analysis of those 354 qulified medical records of contemporary renowned Chinese medicine practitioners, the results were aligned with both the traditional knowledge and current clinical practice, proving that using data mining method in medical records is effective and realistic. At the same time, new knowledge could be found. The expectation of knowledge discovery was achieved and implicit knowledge which is released could be used in clinical reference.