| Acne (Acnevulgaris), this is what we usually call "acne", as occurs in adolescence, the shape of pisiformis, it has known, belongs to the scope of skin disease. It occurred with the human body endocrine glands function, once the loss of function of normal regulation will in human facial hair follicle and sebaceous gland formation repeated episodes of chronic inflammation, and comedones, papules, pus pimple or nodules, cyst. According to relevant data, acne incidence ratio is about 1:5, which is close to half of the adolescent population, some foreign area youth incidence rate also exceeded 90%. Generally speaking, the incidence of male ratio is not lower than that of the female, but because women pay more attention to the appearance of so in the clinic research often appears in female patients for disease. With the quality of life and economic conditions improve, people’s requirement of beauty is also more and more high, the individual looks super attention, so the prevention and treatment of acne is the urgent needs of adolescents. Acne in pathological change type is chronic inflammation, the lesion area in hair follicles and secretion exuberant sebaceous glands, which are easy to part of the disease is the human face and chest and back, because these parts are sebum secretion more active site. The further development of acne, can produce blackheads, papules, pustules, cysts and nodules lesions like lesions. In TCM classic acne free of disease, but there are a lot of acne and pathology of other disease name, generally speaking, the name of the disease is named according to the characteristics of disease location and skin lesions, acne, pimples, acne, lung wind acne different disease. The disease name on the one hand reflects the acne lesions is generally in the face, but also reflects the acne susceptible population is hot blooded youth. According to the characteristics of the pathogenesis and development of diseases, traditional Chinese medicine believes that the main pathogenesis of acne vulgaris is the accumulation of heat in lung and stomach, fumigation face or consider excessive, blood feud, and imbalance of Chong Ren, resulting in skin Shuxie smooth hair, or over eating spicy greasy things, spleen stomach damp heat accumulation, erosion of the skin. In the traditional Chinese medicine theory, the human ear is not isolated, but has a close relationship with the viscera. Ear as human collection organs of perception of sounds, and internal organs of the physiological activity, pathological changes are inextricably linked, and be as close as lips and teeth. The ear is connected and numerous meridian echoes. Hand Taiyang small intestine meridian and the foot Shaoyang meridians are connected directly to the ear, and hand Yangming meridians don’t also and the ear have direct contact, Foot Yangming, foot sun meridians of the two meridians although there is no direct access to the ear, but was followed by the front and upper. Except the twelve regular meridians, eight extra meridians, Yin Qiao, Yangqiao pulse, positive dimensional pulse and three eight is directly related to the ear is communicated, this study through the establishment of common western medicine as control, in randomized clinical trials on magnetic beads auricular point sticking therapy in the treatment of acne vulgaris pressure to carry on the curative effect observation, and skin symptoms score, systemic symptom counts score subsidiary, the curative effect were effective evaluation, in order to explore the magnetic beads auricular plaster therapy the clinical curative effect of treating acne, so as to provide guidance for our future clinical work and research work.Objective:This topic through the establishment of the conventional acupuncture as control, to observe the magnetic beads Auricular Pressure in the treatment of acne vulgaris in patients with skin symptoms score, systemic symptom counts score changes, and after statistical analysis of magnetic beads auricular point taping and pressing therapy in the treatment of acne vulgaris treatment efficacy.Method:The clinical study of all included patients with acne vulgaris were recruited in the Guangzhou University of Chinese Medicine First Affiliated Hospital Department of acupuncture and moxibustion outpatient and dermatology clinic were recruited time began in 2015 during February March to 2016, included in the total number of cases is 60 cases. Patients enrolled in this clinical observation, strictly abide by the randomized controlled trials of guiding ideology, using a random number table method average Fibonacci were divided into experimental group and control group. Treatment: the experimental group and the control group respectively according to the following scheme for processing, in addition, two groups of patients daily should be ready to clean the face, with mild facial cleanser cleansing facial excess oil and avoid direct sunlight. (a) treatment in experimental group: the experimental group using the ear acupoint magnetic bead pressure therapy. The acupoints:Auricular Shenmen, endocrine acupoints, lung, large intestine meridian and subcortical areas.2) operation:each post auricular before, first with alcohol cotton ball will parts of the routine disinfection, to prevent the press after infection, adhesive tape and then 0.5 cm x 0.5 cm in size diameter is 2 mm in size of bead is fixed on the corresponding ear acupoint. Enjoin patient each said press 2 times, each press of 5 minutes, each press must be burning, swelling, especially with pressing ear and frequency have glowing feeling is preferred. Do not wash bath and wet plaster paste, once every 3 days, two ear, total course of treatment for 4 weeks. (two) the control group treatment:control group was given 0.025% vitamin A acid cream. Enjoin patient self clean face, with a clean cotton swab apply tretinoin cream smear on the skin irritation,1 times a day, in the evening before going to bed applicator. The total course of treatment with the treatment group. Evaluation indicators:(a) treatment efficacy evaluation: in the test process was observed in the test group and the control group of patients with acne lesions distribution location, size and color, and the basic information of the patients are in accordance with the following two scores table registration, should be fully aware of the patient’s general condition, should also be the main symptom and accompanying symptoms, including tongue and pulse) are registered in the record book. Main outcome measures:the skin lesion symptom score table, comprehensive evaluation of the main therapeutic effect of each treatment plan. The scale score is papules, pustules, nodules, cysts and other damage to the skin of the number and the distribution of site score, score of the project are mainly 4, namely type of skin lesion, skin lesions and number of swollen and broken, the skin’s color. Each project is divided into 4 serious levels, followed by 0 points, 2 points,4 points,6 points, and finally calculate the total score. Secondary outcome measures:the whole body symptom score sheet, with the aid of the evaluation of significance. Assessment content includes complexion, emotion, itching, taste, urine, stool, sleep, stomach, menstrual (only female patients). The score is divided into two levels, the normal rating is 0 points, the exception was rated 1 points. The two scores were evaluated once every 2 weeks before treatment and in the course of treatment, that is, a total of 3 times, in order to observe the therapeutic effect of each treatment plan on acne in the whole, (two) treatment efficacy criteria to determine the criteria for the main efficacy of the skin lesions syndrome score for the criteria to determine the criteria, divided into four levels to assess.Results:Collected a total of 60 patients observed in this clinical study, the clinical observation, did not appear to reject or shedding cases, did not appear for accidents or adverse reactions, all 60 patients successfully completed observation. Test in test group and control two groups with gender proportion of statistics to compare, by chi square test and chi square 2=0.2715,0602> 0.05. Test group and control group, two groups of patients with age composition ratio statistics to compare, the distribution of two age groups by chi square test and chi square 2=0.3098, P=0.857> 0.05, no statistically significant differences at baseline. In test group and control group after the type of skin lesion score, type of skin lesion score of two groups of patients at 2 weeks have been compared with those before treatment has obvious improvement, and to the end of four weeks, the whole course of treatment, type of skin lesion scores of the two groups was significantly lower than that of the score before treatment, after the repeated measurements analysis of variance, F=0.125, P=0.725> 0.05, the experimental group in the whole treatment course of type of skin lesion score and the control group no obvious statistical difference. In the experimental group and control group after lesions of the number of score comparison, you can clearly see, two groups of patients with lesions of the number of score in the second week has been compared with those before treatment has obvious improvement, and to the end of four weeks, the whole course of treatment, score the number of lesions in the two groups was significantly lower than that of the score before treatment, after repeated measurement data by analysis of variance, F=0.386, P= 0.537> 0.05, the experimental group in the course of lesions of the number of scores between two groups between no obvious statistical difference. In the experimental group and the control group after the swelling rupture score comparison, swelling of the two groups of patients with rupture score at 2 weeks have been compared with those before treatment has obvious improvement, and to the end of four weeks,-the whole course of treatment, two groups of swelling rupture score was significantly lower than the score before treatment and after the repeated measurements analysis of variance, F=0.137, P=0.713> 0.05, namely experimental group swelling in the course of the rupture between the score and the control group had no obvious statistical difference. In the experimental group and the control group after the color of skin lesion score comparison, two groups of patients with lesions of the color score at 2 weeks have been compared with those before treatment has obvious improvement, and to the end of four weeks, the whole course of treatment, the skin color scores of the two groups were was significantly lower than that of the score before treatment, and test scores in group improved more significantly. After analysis of variance of repeated measurement data, F=4.250, P= 0.044< 0.05, namely experimental group throughout the course of treatment of skin color score between the two groups exist statistically significant difference, the experimental group improved more significantly. In comparison, the overall scores of experimental group and control group after the skin lesions, the two groups of patients with lesions of the color score at 2 weeks have been compared with those before treatment has obvious improvement,2 weeks after compared the overall score before treatment, experimental group have t=14.7351, P= 0.00< 0.05; control group t=12.8826, P= 0.00< 0.05, the treatment in the two groups were in the first 2 weeks after have significantly improved, and the difference is statistically significant. And after second weeks, the experimental group compared with the control group, t=-0.9676, P=0.3373> 0.05, there was no significant difference in the treatment of the two groups. In fourth weeks, after repeated measurement data analysis of variance overall score of the two groups of patients after F=0.028, P=0.867> 0.05, the overall score of the two groups improved no statistically significant differences. In the test group and the control group counts the general symptom score were compared between the two groups, each group after treatment all symptoms are lower than before treatment, and in second weeks, has been showing a decreasing trend. But after the chi square test, compared with the control group, using magnetic beads auricular pressure therapy, the experimental group, to reduce the count of the emotions, urine, stool, sleep, stomach, menstruation symptoms were significantly lower than that of the control group, the difference is statistically significant (P< 0.05) and from the first 2 weeks after began to show advantage. Other symptoms had no significant difference (P> 0.05) to judge the curative effect of treatment according to the effective rate to calculate. After calculation and comparison, the experimental group clinical recovery in 2 cases,18 cases were markedly effective, effective in 8 cases, ineffective in 2 cases, clinical cure rate of 6.7%, markedly effective rate was 60.0%,26.7% efficiency, the inefficiency of 6.7%; while in the control group,1 cases of clinical cure, markedly effective in 23 cases, effective 4 cases, invalid in 2 cases, clinical cure rate of 3.3%, markedly effective rate was 76.7%, rate of 13.3%, invalid rate of 6.7%. After rank sum test, the two groups were compared, z=0.757, P=0.4490> 0.05, the difference was not statistically significant.Conclusion:Above all the research results and discussion and analysis, we make the clinical research conclusion:using magnetic beads auricular plaster therapy in the treatment of acne vulgaris, can effectively improve the patients with acne skin lesions and systemic symptoms, so as to achieve the purpose of treating acne and its treatment effect should be medicine of commonly used Tretinoin Cream therapeutic effect can be achieved, and compared, magnetic beads auricular point pressing therapy can improve skin color and emotion, urine, stool, sleep, stomach, menstrual and other systemic symptoms and improve the quality of life of the patients. |
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