Research Of Human Defective Mandible Reconstruction And Biomechanical Analysis Based On Rapid Prototyping Manufacturing

With the rapid development of science and technology, advanced manufacturing technology is looking toward high precision, high speed, high efficiency, processing production of composite materials direction. Rapid prototyping manufacturing technology with many advantages developed in the1980s is a kind of new advanced manufacture technology, and it is a major breakthrough on the world manufacturing technology areas in the last20years. Rapid prototyping manufacturing technology is the technology integration of mechanical engineering, computer technology, numerical control technology and material science and so on. Because of the special forming principle of rapid prototyping manufacturing technology, the technology is very suitable for manufacturing complex biological medical model, such as the human mandible, etc.Computer modeling and simulation which provides the important means for human mandibular biomechanical simulation analysis has become an important technology of manufacturing development in the21st century. How to achieve the purpose for improving the operation accuracy, shortening the operation time, optimizing operation program and reducing pain of patients with existing technologies to make a biomechanics analysis effectively in the actual human mandibular occlusion, has become the problem demanding prompt solution of mandibular biomechanics simulation analysis.This subject supported by the relevant project fund, the cross-disciplinary of advanced manufacturing technology and biomedical engineering was researched. Some key techniques of rapid prototyping manufacturing technology-based human defect mandibular reconstruction and biomechanics analysis were made of modeling, simulation analysis and clinical research study with adopting rapid prototyping manufacturing and computer modeling and simulation technology to provide important reference for its structure optimization,clinical operation plan scheme and design. At the same time, this subject with great value, significance and certain advancement and frontier has achieved the purpose of improving the operation accuracy, optimizing operation schemes, shorten operation time and reduce pain of patients. The main research contents of text as follows:(1) The research background and status at home and abroad was discussed, and the necessity and significance of the subject was analyzed. The development present situation of rapid prototyping technology was summarized in biomedical application. Domestic and international development condition of computer modeling and finite element biomechanics simulation technology was introduced. The necessity and frontier of cross-disciplinary study for human body defect mandibular reconstruction and biomechanics analysis based on rapid prototyping manufacturing technology was demonstrated.(2) Aiming at Chinese Medical Sciences University stomatological hospital clinical cases which were with the understanding inadequately problems leaded by lack of patients’3D model before mandibular tumor operation, the data transmission between DCIOM format data of spiral CT and PC machine was researched through adopting the3D CT reconstruction technology based on reverse engineering. The reconstruction process from the human body mandibular2D CT data to3D digital model, the virtual reconstruction and plant modeling of defect mandibular were finished to have achieved the purposes of preoperative accurate diagnosis and optimize the operation program.(3) Subject adopts the personalized and multi-platform collaboration modeling technology platform for specific patients. With the problems of implanting titanium plate’s standardization and mismatching in the process of traditional mandible reconstruction surgery, researched the mandible of specific patients titanium plate individuation modeling method, established mandible titanium plate personalized model, achieved the purpose of optimal design personalized titanium plate3D model. With the fatigue damage in the process of using titanium plate, to titanium plate for fatigue simulation analysis, optimization titanium plate structure, so as to improve the service life of titanium plate.(4) Adopting the human mandible FEA modeling method based on the reverse engineering CT data, studied and established the original tumor resection patients with mandible, reconstruction after the implant body mandible distraction and implanted the FEA model method. And performed a variety of mandible model in different load cases biomechanical analysis using bone biomechanical and fern integrated simulation technology based on this model, so as to optimize the design scheme of dental implants, improve the precision and lower the surgical risk.(5) Using spray rapid prototyping manufacturing and personalized design auxiliary mandible reconstruction technique, with the problems of traditional mandible reconstruction titanium plate of unified, styling time long and postoperative complications of existence, researched manufacturing mandible RP model and personalized implant titanium plate method. Because of preoperative design and manufacture of the mandible distraction and individualized RP models implanted titanium plate, it had been avoided to spend hours modeling the mandible titanium plate during the operation, and achieved the purposes of shortening operating time, improving the success rate of operation and allaying the patient pain.(6) With the problems of long time, high risk and patients suffering greater pain in the process of traditional mandible reconstruction surgery of Chinese Medical University oral cavity hospital actual clinical cases, subject research results RP technology had been applied to clinical trials. Through the clinical verification5cases and comparative analysis of typical case, it could be concluded that application of RP technology in the mandible reconstruction surgery could shorten the time of surgery about two hours, improve the mandible repairing quality and surgical precision, relieve pain and reduce surgical risk, etc. After3months the graft section contrapuntal healed well, occlusion movement, language and swallowing function was normally and clinical practical utility was obvious.