Study On Relationship Between TCM Of Precancerous Lesion Of Chronic Atrophic Gastritis (PLGC) With PGI、PGII And PGR

ObjectivePrecancerous lesion of chronic atrophic gastritis (PLGC) is one of the most common and multi-occurred diseases in the digestive system which is hard to be cured, and there is cancerous trend especially those with intestinal metaplasia/atypical hyperplasia, so it is increasingly getting the social attention. Active prevention, early diagnosis and treatment are of significance for preventing gastric cancer.The purpose of this research is to study the correlation between different TCM syndrome types and positive serologic test results of chronic atrophic gastritis precancerous according to the examination of serum pepsinogen (PG) as a result, then to identify the TCM syndromes with highest risk of cancer, so as to provide an early warning for the clinical treatment.Contents and MethodsBased on TCM basic theory and related medical literature research, diagnostic data of 133 PLGC patients diagnosed through electronic gastro scope and gastric mucosa pathological biopsy were collected through clinical expert consultation method, TCM dialectical thinking and epidemiological cross-sectional survey research methods. TCM syndrome types were identified through "The Nakedness of Chronic Atrophic Gastritis to Cancer Associated Card Syndrome Differentiation System".The serum pepsinogen (PG) results which were detected by Synchronization chemiluminescence method had been divided into four grades, which were negative, mild positive, moderate positive and strong positive according to the serum PGIâ…  PGâ…¡ and PGI/PGâ…¡ ratio (PGR).Data processing and statistical analysis using PASW Statistics 18.0 statistical analysis package, mean+standard deviation (x+s), the median (M), the maximum (Max) and the minimum (Min) were used to descriptive analysis the measurement data, in which the normal distribution test was conducted. The counting data was described by proportion and ratio. The inferential analysis:The measurement data:The normal distribution data with homogeneity of variance between groups was compared by t test and variance analysis, while the non-normal distribution data without the homogeneity of variance between groups was compared by rank sum test. (2) The counting data:chi-square test or Fisher method were used to compare the rate between groups. (3) The level data:comparison between groups using rank sum test (the Mann-Whitney method), Logistic regression analysis, correspondence analysis and other multiple factors analysis method were used to analysis the correlation between different TCM syndrome types and positive serum PG test results of patients with chronic atrophic gastritis precancerous. The test level is ï¼°=0.05.To study the correlation between different TCM syndrome types and positive serologic test results of chronic atrophic gastritis precancerous according to the analysis of two categories (single syndrome types and deficiency and excess correlation syndrome types), then to identify the TCM syndromes with highest risk of cancer Results1. TCM syndromes distribution:49 cases.accounted for 34.84% of the total,were with single syndrome type, including 12 cases of damp-heat retention stomach syndrome (9.02%), stagnation of liver-qi and stomach-qi syndrome in 15 cases(11.28%), stomach Yin deficiency in 12 cases (9.02%), deficiency cold of spleen and stomach syndrome inlO cases (7.52%); 84 cases.accounted for 63.16% of the total,were with deficiency and excess correlation syndrome, among which stagnation of liver-qi and stomach-qi syndrome/qi-Yin deficiency syndrome in 22 cases (16.54%), stagnation of liver-qi and stomach-qi syndrome in 15 cases(11.28%), stagnation in stomach collaterals/qi and Yin deficiency syndrome in 21 cases (15.79%),15 cases of damp-heat retention stomach syndrome/stomach Yin deficiency syndrome (11.28%), damp-heat retention stomach syndrome/deficiency cold of spleen and stomach syndrome in 26 cases (19.55%)2. The testing results of serum pepsinogen:26 cases were negative(19.55%), while,53 cases Mild positive(39.85%),36 cases moderate positive(27.07%), and 18 cases strong positive(13.53%).3. The correlation between all syndrome types and positive test results of serum pepsinogen:Negative is common in patients with stomach Yin deficiency syndrome, Stagnation of liver-qi and stomach-qi syndrome/qi Yin deficiency syndrome, damp-heat retention stomach syndrome/stomach Yin deficiency syndrome, Mild positive is common in patients with deficiency cold of spleen and stomach syndrome, damp-heat retention stomach syndrome and stagnation of liver-qi and stomach-qi syndrome; moderate positive-strong positive is common in patients with stagnation in stomach collaterals/qi and Yin deficiency syndrome, damp-heat retention stomach syndrome/deficiency cold of spleen and stomach syndrome whose serum PGI level and PGR degree decreased significantly.Conelusion1.The TCM syndrome types of PLGC in the majority are with deficiency and excess correlation syndrome, and syndrome structure has the characteristics of polymorphism and dynamic;2. Moderate positive-strong positive is common in patients with stagnation in stomach collaterals/qi and Yin deficiency syndrome, damp-heat retention stomach syndrome/deficiency cold of spleen and stomach syndrome3.The syndrome types of PLGC with high-risk of cancer may be damp-heat retention stomach syndrome/deficiency cold of spleen and stomach syndrome whose, stagnation in stomach collaterals/qi and Yin deficiency syndrome.