The Research On Oncology Derivation And Development Based On Knowledge Network

Purpose:This study aims to adopt the methods of a combination of theory with practice, and ofqualitative with quantitative, that is, a combination of scientometrics theory and theoncology practice based on knowledge network, and an integration of the theories,models, empirical evaluation and countermeasure research, to try to depict thescientific knowledge maps of the mainstream oncology disciplines and itself.Oncology research fronts, hotspots and evolution trajectory is revealed, oncologydiscipline structure and its derivation and development is explored, and its position inthe groups of biomedicine disciplines is clearly defined, so as to timely trace theinternational forefront and strengthen international cooperation for Chinese oncologyresearch, and to supply decision-making basis for Chinese oncology disciplinedevelopment and biomedical technology management.Data:International data: All the literatures related to oncology with format ’articl’ and‘review’ from the SCI-EXPANDED, CPCI-SSH of Web of Science database from1912to2012are retrieved.Chinese data: All the data from10core oncology source journals in China in the lastdecade are collected.Methods:1. Literature analysis2. Integrated analysis of visualization methods: keyword analysis, documentco-citation analysis, author co-citation analysis, journal co-citation analysis anddiscipline co-citation analysis 3. Integrated analysis of multivariate statistical methods4.Integrated applications in social network analysis and statistic softwares: CiteSpace,Pajek, Bibexcel, SPSS, SAS and Wordsmith5.Empirical methodsResults:1. The knowledge maps of oncology research domains, we found that the citationfrequency of the US accounted for53.8%of the total citation frequency of the top20core countries performing oncology research. China is the sole developing country toenter the top10. Within the core institutions of oncology research, the US accountedfor18of the top20institutions, and its total citation frequency accounted for93.5%of the top20. The research strength of the University of Texas, the NCI and HarvardUniversity has steadily grown for nearly10years, and most countries and institutionshave separate and distinct research directions. It is clear that the United States is theleading country in oncology research. We found that the current oncology researchfronts are focused in four fields:(1) the mechanism of abnormal oncogene expression,(2) tumour metastasis and angiogenesis,(3) the relationship between cancer cells andapoptosis, and (4) tumour vaccines. The four research frontiers included55branchfields.The study also identified the36most collaborative academic communities andstated that their oncology research strength is basically in balance. Multiple myeloma,angiogenesis, and acute lymphocytic leukaemia were the primary focuses of researchcollaborations in oncology from2001to2010. This study reveals that researchersfrom Beijing, Shanghai, and Guangdong cooperate most closely with each other andthat the collaboration within ‘Administrative Divisions’ is closer than that betweenthem, and the closer collaboration groups are among the State Key Laboratory ofHuanan Oncology,Affiliated Oncology Hospital of Fudan University, Cancer Instituteand Hospital of Chinese Academy of Medical Sciences, Peking Union MedicalCollege Oncology Hospital and Institution, Tongji Medical College of HuazhongUniversity of Science and Technology, No1Affiliated Hospital Oncology of Zhengzhou University, Peking University School of Oncology, Anhui MedicalUniversity Affiliated Provincial Hospital, Shanghai Jiao Tong University School ofMedical Affiliated Ruijin Hospital, Shandong Provincial Oncology University, etc.These institutes function as ‘incubators’ for Chinese Oncology research and are majorplayers in this field.2. The analysis of oncology branch disciplines and its structure showed themainstream branch disciplines of oncology are clinical oncology, oncologyepidemiology, oncology radiation, oncology diagnostics and immunology. Overall,clinical oncology and molecular biology are the maternal disciplines, cancer genetics,tumor pathology, tumor etiology, experimental oncology and epigenetics are its mainemerging disciplines and cross-disciplines, which suggested Epigenetics may developinto the leading one.3. The empirical studies illustrated oncology pathology, oncology surgery, oncologyepidemiology, oncology therapy, oncology etiology, oncology pharmacology,molecular biology of oncology, oncology diagnosis, oncology immunology,oncology genetics and oncology imaging are11major elements; During the past100years, oncology discipline structural elements were dynamic, the discipline structurecenter was continually shifted, which promoted the development of oncology for thelink and moving among these elements.Findings:The study demonstrated the derivation and development law of oncology disciplines.1. Oncology derivation and development has gone through the course ofdifferentiation to integration, and to differentiation.2. The breakthrough of new technologies, new methods and new theories in scienceinternal is the direct driving force in the development of oncology disciplines.3. The appearances of interdisciplinary and emerging disciplines are its track anddirection for oncology derivation and development.Innovation points of view in this study:1. By using multi-angle and multi-dimensional integration of innovative approaches,mainly in the combination of quantitative analysis and scientific knowledge maps, the oncology trends and laws for derivation and development were traced andanalyzed.2. A theoretical model for oncology derivation and development was built, which isverified by an empirical research and case studies.Conceptions for making further study:1. As a strong complement to quantitative data of journal papers, online surveys,e-mail, questionnaire design and other qualitative research should be carried out for asupplement of books and clinical case reports related to oncology. Combination themeta-analysis and scientific metrology methods to examine oncology developmenthotspots and its law from sociology, psychology and other perspectives.2. A century-data of breast, liver, kidney and other oncologies should be collected,and time slices will be divided according to the Great History Chronicle in thedevelopment of life sciences, so as to make a further research on oncology derivationand development.