| ObjectiveThis research was aim to study the effect of Dingjingtang and Erzhiwan in treating menstruation, and evaluate the safety of the treatment for providing scientific basis in clinical application.MethodThe60cases objects was collected from January2011to November in Taiwan, Kaohsiung Municipal Renda TCM clinic late menstruation patients whom meet the inclusion criteria according to the principle of randomly divided into2groups. According to the method of random control, strict control of variable factors, the participants were randomly divided into treatment group and control group,30cases each group. Control group:treatment for regulating the liver and kidney, nourishing menstruation. The control group was treated with Xiaoyao Pill.Xiaoyao Pill drug composition:Caihu, Danggui, Baishao, Baizhu(fried), Fulin, Gancao and Bohe. Directions:use of Xiaoyao Pill (Jiuzhitang Ltd. Co., the country medicine accurate Z20013060),9g/time, three times a day, take one week after operation, three months for a course of treatment, and3months of follow-up after stopping drug. The treatment group was cured for nourishing liver and kidney, nourishing menstruation, the decoction for the treatment of the decoction mixed Ding Jing Tang and Erzhiwan. Ding Jing Tang was composed of Shudi, Danggui, Baishao, Caihu, Fulin, Shanyao, Tusizi, Jinjiesui. Erzhiwan was composed of Nvzhenzi and Mohanlian. With qi and blood deficiency was added Dangshen and Huangqi; with phlegm stagnation was added Sharen and Baizhu; with deficiency-cold was added Xiangfu and Rougui. Take one week after operation, three months for a course of treatment, and3months of follow-up after stopping drug. Before and after treatment in all patients should be according to the requirements detailed in the observation table, evaluation and make the effect after the end of treatment.Statistical methods:classification of data with χ2test, ranked data for two samples Wilcoxon test (calibration), two samples were compared using t test or Wilcoxon test, the t test for comparison or Wilcoxon paired rank sum test.ResultThere were60cases in the group of eligible patients:the treatment group and the control group of30cases. Before treatment, two groups of patients with age, menarche, duration time of TCM symptoms, basic body temperature, serum sex hormone FSH (follicle stimulating hormone), LH (luteinizing hormone), E2(estradiol), T (testosterone), there were no statistical significant difference. The two groups were comparable.After a course of treatment, the treatment group can significantly reduce the clinical symptoms score (P<0.05), and3months after treatment stopped in the symptom score reducing rate is still better than those of the control group (P<0.05). And the total curative effect of TCM syndrome, Xiaoyao Pill and control group in the total efficiency was50%, and the treatment group total effectiveness is86.66%. The treatment group curative effect surpasses the control group. From the improvement of the basal body temperature, the control group after a course of treatment,40%efficiency. The treatment group was73.33%, the treatment group with the basal body temperature was significantly better than the control group. The control group and the treatment group had significantly decreased FSH, increased E2. And the comparison of two two changes of group and the treatment group, there were significant differences in FSH, E2(P<0.05). The treatment group was significantly better than the control group.After stopping the treatment after three months, compared with two groups of total curative effect of TCM syndrome, there was significant difference. The control group in the total efficiency of63.33%, the total effective rate in treatment group was90%. The treatment group curative effect surpasses the control group. To improve the situation of the basal body temperature, the control group after a course of treatment,50%efficiency. Effective rate of treatment group76.66%, treatment group was significantly better than the control group (P<0.05). FSH after the two treatment, the comparison, decreased significantly (P<0.05). E2after the two treatment, increased significantly (P<0.05). Comparison between the two two changes of group and the treatment group after treatment, FSH, E2, LH, PRL, T had no significant difference.ConclusionDingjingtang and Erzhiwan in treating menstruation has significantly clinical efficacy, after treatment, the treatment group can improve TCM syndrome score and can significantly reduce the symptoms of Chinese medicine. The two groups after treatment the serum FSH (follicle stimulating hormone) decreased significantly, E2(estradiol) level, and the treatment group for the basal body temperature regulation is better than that of control group. Three months after discontinuation of treatment effect, TCM syndrome score group can, and effectively improve the basal body temperature. Dingjingtang and Erzhiwan in treating late menstruation had significant therapeutic effect, and the effect is lasting, after treatment condition is not easily repeatedly. So the Dingjingtang and Erzhiwan in treating menstruation had clinical value. |
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