Research On Lung Cancer Clinical Treatment And Drug Law Of Professor Liu Weisheng

BackgroundThe famous old Chinese doctor is wealth in the field of traditional Chinese medicine, they work for decades. They accumulated rich experience in the diagnosis and treatment in the long-term medical practice. Inheritance of academic thinking and experience of the old and well-known Chinese medicine doctors, can improve the medical technology of current doctors of traditional Chinese medicine, can improve the traditional Chinese medicine theory, can promote the young doctors, has the very vital significance. After decades of clinical practice, his theory foundation is very solid, he accumulated the experience of diagnosis and treatment of many diseases.Object i veTo organize the relevant aspects of diagnosis and treatment of lung cancer, and analyze Chinese and western medicine study of lung cancer; use the method of clinical epidemiological investigation and literature retrieval method, and then create database about Professor Liu Weisheng’s clinical experience and drug law to summarize the clinical experience of Professor Liu Weisheng and his drug law.MethodBy the method of retrospective survey, this study collected in January1,2008to December31,2011, Guangdong hospital professor Liu Weisheng’s lung cancer cases. Through excel software and Shanghai Tongji University data mining software (TCM clinical information resources mining platform: http://levis.tongji.edu.cn/medweb), professor Liu Weisheng’s clinical diagnosis and treatment information database were established. Using of mathematical statistics, data mining techniques, factor analysis, cluster analysis, survival analysis and other methods to summarize the clinical experience of Professor Liu Weisheng and his drug law.Result1. Syndrome characteristics1.1General characteristicsCollected a total of182cases of patients, including113men(62%) and69women(38%). The average age for men was63.12±9.94,58.46±11.68years old for women. The median age of patients was62years, onset age concentrated in over60years old (111cases,61%). Treatment5-9times the number of101cases (55.5%),10-19times in54cases (29.7%), more than20times in27cases (14.8%). The frequency of treatment is up to50, at least5times. Male patients attending times to12.12±9.11, female patients was13.36±10.12. History of the longest was211months, the shortest was2months, average duration was32.11+26.41months.80patients with primary site in left lung (44%) and in the lungs of patients with99cases (52.2%).128patients with peripheral lung cancer accounted for70.3%,29cases of central type lung cancer accounts for15.9%. Lung cancer staging in patients with stage Ⅰ in26cases(14.3%) and21patients with stage Ⅱ (11.5%), patients with stage Ⅲa27cases(14.8%), patients with stageⅢb22cases(12.1%) and patients with stage Ⅳ60cases (33%).1.2Symptoms and signsPatients with the most common symptoms of cough,1421times (63.3%), cough up phlegm,1224times (54.5%), shortness of breath,761times (33.9%), lack of737times (32.8%), etc. TCM tongue like:dark red tongue moss white239times (10.6%), dark red tongue moss yellow205times (9.1%), red tongue moss white200times (8.9%). TCM symptoms, the most common pulse condition is:pulse string441times (19.6%), pulse string slip429times (19.1%). Among182patients with lung cancer, deficiency of both qi and yin (59cases,32.4%), yin deficiency and toxic heat (9cases,4.9%), accumulation of phlegm-dampness (52,28.6%) and blood stasis resistance lung collaterals (62,34.1%).1.3Transfer caseGender factor analysis with distant metastasis, difference was statistically significant (χ2=3.79, P<0.05). Female than male patients prone to patients with distant metastasis. Treatment more frequently in patients not prone to distant metastasis, the difference was statistically significant (χ2=20.48, P=20.48). The age factor did not affect distant metastasis, the difference was not statistically significant(χ2=3.54, P=0.32). Central and peripheral, two groups of distant metastases no difference, the difference was not statistically significant (χ2=4.26, P=0.24).The surgery can be delayed in patients with distant metastasis, the difference was statistically significant (χ2=2.11, P=0.15).The patients did not undergo targeted therapy can be delayed distant metastasis, the difference was statistically significant (χ2=3.43,P=0.06). The treatment is more, the less distant metastasis(P<0.05). The tumor disease staging Late prone to metastasis (P<0.05).2. Professor Liu Weisheng’s experience in diagnosis and treatment of lung cancerThe most commonly used drugs are:Herba Scutellariae Herba Scutellariae Barbatae(2068,92.12%), Hedyotis diffusa (2041,90.91%), Scorpion(2036,90.69%), Glossy privet fruit (1902,84.72%), Centipede (1784,79.47%)，Chinese magnoliavine fruit (1682,74.88%), Radix Ophiopogonis (1672,74.88%), Peach seed(1514,67.44%), Semen coicis(1359,60.53%), Reed rhizome (1292,60.53%), Fructus Psoraleae(1273,56.7%).Herba Scutellariae Barbatae+Hedyotis diffusa (2021,90.0%),Scorpion+Centipede (1734,77.2%), Radix Ophiopogonis+Heterophylla (1138,50.7%), Dipsacus+Fructus Psoraleae (1122,50.0%), Heterophylla+Radix Ophiopogonis+Chinese magnoliavine fruit (1104,49.2%), Herba Scutellariae Barbatae+Hedyotis diffusa+Scorpion+Centipede (1592,70.9%), Reed rhizome+Semen coicis+Peach seed+Melon kernel (797,35.5%), Fructus Psoraleae+Epimedium+Dipsacus+Glossy privet fruit (655,29.2%).Drugs for clustering analysis, the results show the first category are Herba Scutellariae Barbatae, Hedyotis diffusa, Scorpion, Centipede, Chinese magnoliavine fruit, Radix Ophiopogonis, Heterophylla, Glossy privet fruit, Licorice. The second category are Peach seed, Reed rhizome, Semen coicis, Melon kernel, Herba Houttuyniae, Scutellaria. The third category are Epimedium, Fructus Psoraleae, Dipsacus, Codonopsis, Astragalus, Fructus Amomi. The fourth category are catclaw buttercup root, Mulberry, Glossy privet fruit. In clinical Shengmaisan accounted for70.5%, Weijing decoction accounted for35.5%.Conclusion1. Syndromes aspects1.1In this study, male patients are more than women. The majority of men is in the58-68age group, the majority of women is in the48-58age group. Patients with peripheral lung cancer and adenocarcinoma are more. The most common clinical signs and symptoms are cough, expectoration, fatigue, weakness, shortness of breath, dry mouth, chest pain, headache, dizziness, loss of appetite, poor sleep, red or dark red tongue, moss white or yellow, pulse string or string slide.1.2Single factor analysis showed that gender, diagnosis, operation, targeted therapy, factors related to tumor distant metastasis. Age, location of lung cancer, different types do not affect the tumor distant metastasis. Multi-factor analysis showed that clinical factors, partial factors are independent prognostic factors for patients with distant metastasis. This study found that long-term use of traditional Chinese medicine treatment can be postponed in patients with distant metastasis tumor.2. Summaries of professor Liu Weisheng’s experience2.1The basic pathogenesis of lung cancer:Deficient vital qi leading to lingering of toxic.2.2The basic treatment of lung cancer:Tonifying qi and yin and eliminating phlegm, clearing away heat andtoxic materials and removing blood stasis.2.3The syndrome differentiation of lung cancer:syndrome of blood stasis obstructed in lung collaterals, syndrome of deficiency of both qi and yin, syndrome of turbid phlegm obstructing lung, syndrome of Yin deficiency heat toxin.2.4The most commonly used in traditional Chinese medicine prescriptions: Shengmaisan and Weijing decoction.2.5The most commonly used drugs:Herba Scutellariae Barbatae, Hedyotis diffusa, Scorpion, Glossy privet fruit, Centipede, Chinese magnoliavine fruit, Radix Ophiopogonis, Peach seed, Semen coicis, Reed rhizome, Fructus Psoraleae.2.6The most commonly used combinations:Herba Scutellariae Barbatae+Hedyotis diffusa, Scorpion+Centipede, Radix Ophiopogonis+Heterophylla, Dipsacus+Fructus Psoraleae, Heterophylla+Radix Ophiopogonis+Chinese magnoliavine fruit, Herba Scutellariae Barbatae+Hedyotis diffusa+Scorpion+Centipede, Reed rhizome+Semen coicis+Peach seed+Melon kernel, Fructus Psoraleae+Epimedium+Dipsacus+Glossy privet fruit.