A Study On Sleep Disorders Characteristic Of ChronicFatigue Syndrome And The Efficacy Of Acupuncture

Aim:To explore the characteristics of objective sleep measures and subjective sleep evaluation, sleep quality between Chronic Fatigue Syndrome patients and healthy individuals. And to evaluate the efficacy of acupuncture for CFS sleep disorders.Methods:1. Case-controlled trials was designed. A total of72CFS patients and72healthy individuals were recruited in, Polysomnogram parameters was employed to evaluate the objective sleep, morning questionnaire and PSQI scores to evaluate subjective sleep.2. The randomized controlled trials was carried out,72CFS was randomized divided into2groups followed the ration of2:1, named acupuncture (group A) group and placebo acupuncture (group B). According to different acupoints and acupuncture needles, four sessions of treatment were required in each group,5days in the first week,3days in the seconed and the third weeks, and2days in the forth week, totally13days in the whole period. The primary clinical curative effects of groups were assessed by sleep perception during the enrollment, after4sessions of treatment.The secondary clinical curative effects of groups were assessed by other sleep parameters from PSG, and PSQI scores for the sleep quality during the enrollment, after4sessions of treatment.Results:1. The characteristics of CFS sleep disorders represents as:1)In objective sleep aspect, group CFS patients and healthy individuals group has no statistically difference in total sleep time, sleep latent, awakening number, awakening time, sleep efficiency (P>0.05). But CFS patients has a trend of increased awakening number, awakening time.2) In subjective sleep aspect, the following outcomes of in group CFS patients and healthy individuals were statistically difference:total sleep time, sleep latent, awakening number, awakening time of morning questionnaire (P<0.05). 3) Group CFS patients was statistically different from group healthy individuals in PSQI scores and subscales (P<0.05).4)Group CFS patients was statistically different from group healthy individuals in sleep perception (P<0.05).2. The efficacy of acupuncture for CFS sleep disorders represents as:1)Group A was statistically different from group B in sleep perception after treatment (P<0.05).2)The objective sleep evaluation frome PSG showed no statistically difference between group A and group B after treatment (P>0.05). But there has a trend of Group A for reducing the awakening number and awakening time.3)Group A was statistically different from group B in total sleep time, sleep latent, PSQI scores and subscales after treatment (P<0.05).Conclusions:1. CFS patient has a feature of sleep state misperception. The objective sleep architecture has no characteristic change. Compared with healthy individuals, CFS patients has prolonged sleep latent, awakening number, awakening time, and reduced total sleep time of morning questionnaire, CFS patients has poor sleep quality and daytime dysfunction.2. Acupuncture is more efficacious than placebo acupuncture in relieving sleep state misperception. The objective sleep evaluation frome PSG showed no statistically difference between acupuncture and placebo acupuncture after treatment. But there has a improve trend of awakening number, awakening time. Acupuncture can improve the sleep qulity and total sleep time, reduce sleep latent, PSQI scores and subscales of CFS.