Kashin-beck Tcm Etiology And Pathogenesis And Syndrome Factor Research

Objective:Based on the relevant literature of Kaschin-Beck disease (KBD) in TCM. to summarize etiology and pathogenesis. Combinating modern literature and clinical investigation, to extract syndrome elements (SE) of disease location and nature, to explore the combination rules of SE and syndrome characteristics and criteria on diagnosis, for the syndrome differentiation of KBD to help.Methods:1. TCM Literature Research:Review on ancient and modern literature of KBD, analyze TCM disease name, etiology and pathogenesis. extract SE and analyze the distribution of SE and SE combination rules from TCM syndrome types in nearly30years of KBD modern periodical literature.2.Clinical Research:collect information of957cases of patients with KBD by four diagnostic methods, through syndrome differentiation of TCM expert group in experience and specification for syndrome, permit extraction, establishes corresponding database, using SPSS17.0statistical software package for frequency and the frequency of the descriptive statistics and X2test. And carry on the discussion of KBD SE distribution and combination rule, finally using logistic regression analysis, the preliminary draw common SE diagnosis reference index of KBD.Results:1. TCM Literature Research:(1) Etiology and Pathogenesis Features:The combination of False. Evil, and Blood stasis. False ie. Deficiency of liver and spleen and kidney. Evil ie. the wind and the cold and the dampness. Blood stasis as sense, phlegm and blood stasis cementation. Deficiency of vital qi (liver, spleen, kidney deficiency), evil invasion.(wind. cold. wet. heat invasion), stagnation of phlegm and blood stasis stalemate. eventually leading to bone damage, joint deformation, muscular contracture. (2) SE Extraction Research:By Literature studying on the KBD. Disease location SE includes the kidney, meridian, liver, muscles and bones, spleen and disease nature SE focuses on a wet. cold, yang deficiency, blood stasis, heat, blood deficiency, wind. Qi deficiency, essence deficiency, yin deficiency and phlegm. Combination of disease nature SE mainly concentrated in two, three certificates in combination of SE combination of disease, combination of disease location SE mainly focused on single disease location SE combination, followed by not explicitly disease location SE combination and two.2. Clinical Research:(1) SE extraction of clinical investigation:four disease location SE:kidney, liver, spleen, meridian, twelve disease nature SE:wet, cold, yang deficiency, wind, blood deficiency, blood stasis, essence deficiency, qi deficiency, heat, phlegm, yin deficiency, stagnation of qi. Disease nature SE combination rule mainly in two, four at least; single disease location SE occurs most frequently, three at least.(2) Reference Index of SE Diagnosis:Kidney:Soreness and weakness of waist and knees, low back pain, joint deformity, clear urine in large amounts, deep pulse. Liver:Limb numbness, joint stiffness, limb contracture, depression, string pulse. Spleen:Muscle atrophy, weakness, pale complexion, abdominal distension, moderate pulse. Meridian:Stiffness and pain of head and neck, spasm in nape and back, limb pain, low back pain with foot. Wet:Heavy body trapped, joint swelling, greasy fur, slippery pulse. Cold:Joint pain with cold, aversion to cold, white fur, floating and tense pulse. Yang Deficiency:Fear of cold, cold extremities, pale, prefer warm water, clear urine in large amounts, pale tongue with fat. faint pulse. Wind:Itchy skin, Body pain, aversion to cold. Wandering pain, floating pulse. Blood Deficiency:The pale complexion, dizziness, limb numbness, pale tongue, thready pulse. Stasis of Blood: Tingling, pain to press, pain at night, tongue petechiae, purple tongue. Essence Deficiency:Growth retardation, short stature. Soreness and weakness of waist and knees, creaked intra-articular. loose teeth, swarthy, a weak pulse in chi.Deficiency of Qi:Lack of power, mental fatigue, spontaneous perspiration, weak pulse, shortness of breath, limbs flaccid, pale tongue. Heat:Joint causalgia, fever, yellow urine, red fine, red tongue, less moss oreroded fur, fissured tongue, thread and rapid pulse. Stagnation of Qi:Swell to ache, emotional depression, ungratifying defecation,stringy pulse.Conclusion:TCM name of Kashin-Beck disease is Proposed and etiology and pathogenesis is discussed and summarized systemly.Through the literature and clinical investigation, extract a total of sixteen SE:four disease location and twelve nature.Initially reveals combination rules and common reference index of SE Diagnosis of KBD, improve the understanding of syndrome and diagnostic criteria of TCM in KBD.