| ObjectivesParkinson's disease (PD) is a degenerative disease of nervous system, which is common in middle or/and old Peoples. Incidence of PD is raising as the age increases. Researches on the hypokinesia type and rigid type are scarce since PD was divided into four clinical types in 1984. Hypokinesia type and rigid type account for twenty percent to thirty percent of PD.However, they are ease to be miss diagnosed and misdiagnosed because of the delitescent clinical manifestation. Almost all kinds of PD have symptom of rigidity. Especially in the advanced stage of disease, rigidity,bradykines,hypokinesia and dyskinesia originated from treatment of Madopar are the main causes of disability and lethal complication. Incidence of PD is increasing as aging of population. The objectives of this research is to provide basis for the Traditional Chinese Medical (TCM) recognition of PD (hyokinesia type and rigid type), for summarizing and generalizing TCM therapy on PD (hyokinesia type and rigid type), and for exploitation of new drugs.MethodsThis research is a prospective randomized controlled trial.All the sixty qualified patients come from PD special out-patient or hospital ward. These patients were grouped randomly into two groups:Thirty in Group A, thirty in Group B. Therapy of Group A was:kakkonein injection, one dose QD, together with Madopar 250mg in the morning,125mg in the noon,125mg in the evening; therapy of Group B was only taking Madopar orally, the dose was as same as Group A. Observing cycle of the two groups were both three months. SPSS 11.5 software was used to handle datum. T-test was used to handle quantiative datum and rank sum test was used to handle categorical datum.Resultsprior treatment, gender,age,course of disease,H-Y grading of pathogenic condition and UPDRS of the two groups had no statistical difference (P>0.05). After treatment, in Group A, three cases had no effect or had aggravation, five cases had mild amelioration, twenty cases had amelioration and two case had obvious amelioration. The total effective rate of Group A was 90%. In Group B, nine cases had no effect or aggravation, ten cases had mild amelioration, ten cases had amelioration and one case had obvious amelioration. The total effective rate of Group B was 70%. The difference (P>0.05). After treatment, the difference of UPDRS had statistical significance (P<0.05). As far as H-Y grading of pathogenic condition was concerned, difference of efficacy in the two groups had statistcal significance at the second grade (P<0.05). This indicated that the efficacy had some association with pathogenic condition. The quality of life had improved significantly in test group than that in control group.Conclusionâ‘ The basic pathogenesis of hypokinesia type PD is deficiency of yinxue with losing nourishment of muscle and tendon. Therapy of this disease should be based on lievr and kindney and principle of treatment is enriching blood and softening tendon, which have been proved effect clinically.â‘¡The quality of life had improved significantly in test group than that in control group.â‘¢1HMRS is a valuable tool to detect the metabolic changes in the PD, supports the changes of anatomy in images.1HMRS can detect the reduction of the NAA/Cho,NAA/Cr,Cho/Cr ratios in control groups, which explain that there was a marked amendment in pathological change in test group.â‘£Inadequacy of conclusion:There is low incidence rate in hypokinesia type and rigid type PD. Misdiagnosis and missed diagnosis is hard to be avoided in general outpatient clinic.It's necessary for multicentre and mult-unit to collaborate.; How to make the animal model according to PD'TCM Theory is a hard work.
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