Relation Between Multipul Risk Factor Of Angionosis And Investigation Of Knowledge About Metabolic Syndrom In Luoyang Medical Worker

Objective: There are multipul risk factor of angionosis coexist in one body. It have the feature which can leads heighter relapse rate of vessel disease(VD) and more severe disadvantage then one which have only one risk factor of angionosis .Doing perspective study in some one who have one or more risk fector of VD but have not appear VD to understand the relation between them.Then studying the interaction of mutipul risk factor exist same one and the damage of endangium with animal experiment. Last we investigat to get the message about metabolic syndrome knowledge among medical worker.The aim is to provide some data to Medical Adminstrative Command for formulation preventing VD.Method : The study consists of four parts.Each part is listed as following. First To understand the tuneover condition in human who had metabolic syndrome and had not metabolic syndrome after having first stroke.We got the first stroke patients and divided into two groups, stroke addition metabolism syndrome (A )and simple stroke (B). Taking alike treatment and health education ,we get theire meso-lifetime and the score of neurologic impaiment at first stroke and relapse,and do statistic analyze. Second This study aimed to assess the number of abnormal components in the metabolic syndrome (MetS) and their association with cardiovascular diseases (CVD) in Chinese population. The information available about the abnormal components of the Metabolic Syndrome (MetS) was according to Chinese Diabetes Federation proposed the definition. We conducted a population-based succession study in an urban of Luoyang, based on the number of abnormal we divide five parts in a sampling of 334 participants who age is 36 to 75 years (183 men, 151 women) .To getting the relation between the relaps of VD and the abnormal factor , we observe this sample in two years. The CVD included in this study was diagnosed coronary heart disease (CHD), strokes, and peripheral arterial diseases (PAD).Third Getting 24 SD rats, we divide into two groups A and B randomization. Taking different feeding condition and identical life condition:height fat with water and height fat with diabetin water.Drown blood from the vena caudalis of rat who were fasted during the fore night then the blood sample were carried out biochemical analysis.The markers were total cholesterol(TC) , high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C),fast blood sugar(FBS),insulin(IN),nitric oxide(NO), endothelium-1(ET-1) at the begin ,6 weeks and 12 weeks. Up to the end, killing all rats observes these structure of the two groups rat's internal carotid and basilar artery and cellular structure.Fourth In 2005.12-2006.1,we distrubuted questionnaire to Luoyang medical worker in all 4589. It includes three parts: base concept, detriment,cure and precaution .Every part was dividatured some small parts and becomes quantization.We divided this result according to aged,occupation and educations .To anasis this result with x2。Results The studying show: First The meso-lifetime of merely stroke(A) is 22 months more longger then the meso-lifetime of strok with metbolic syndrom(B) is 13 months. A longger then B.Their statistics is 28.9703, p<0.01 They have obviously statistical significance.Their neurologic impairment score is A24.58±5.63 ,B24.59±6.43 at first falling ill. The score is alike .Their statistics is 0.001, p>0.05. They have not obviously statistical significance.But at second falling ill the score of A is 26.59±4.61,of B is 30.67±5.41.Their statistics is4.06, p<0.05. They have obviously statistical significance.Second There was a significant relationship between the number of abnormal components in the Metabolic Syndrome and Cardiovascular Diseases in Chinese Population. We found a significantly increased prevalence of CHD, Strokes and PAD with an increasing number of METS components. Data were managed using Chi-square test to examine differences in continuous and categorical variables respectively. Mantel-Haenzel demixing Chi-square test was used to study the relation between cardiovascular disease and abnormal component in blood calculate risk ratios (RRs) and their 95% confidence intervals (CI). All analyses were conducted using SAS8 (version 1). The incidence of CVD occurred in population with only one abnormal component was defined as one (the lowest prevalence in the group), in turn the relative risk in each group was deferred. This number could be gotten based on table 1: The RR of CHD in different group is 1.81, 2.65, 4.03, 4.10 for two or more, three or more, four or more and five or more individuals. The RR of Stroke in different group is 1.41, 2.23, 3.30, 3.85 for two or more, three or more, four or more and five or more individuals. The RR of PAD in different group is 1.63, 1.62, 3.22, 5.34 for two or more, three or more, four or more and five or more individuals. We found a significantly higher prevalence of CHD, Stroke and PAD with an increasing number of METS components. after adjusting age we can get that the RR of high blood pressure was 7.27 (95% CI: 4.74 to 11.17) and there was significant difference between the population with normal and abnormal blood pressure. So as the RRs of high fasting glucose, lower high-density lipoprotein, hypertriglyceridemia, and overweight were 4.36 (95% CI: 2.92 to 6.49), 1.52 (95% CI: 1.05 to 2.21), 1.31(95% CI: 0.9 to 1.9), and 2.73(95% CI: 1.86 to 4) respectively. Besides hypertriglyceridemia( statistics is 1.9893,p>0.05) the rest every one have significant difference between the population with normal and abnormal.Thire statistics of high fasting glouse, lower high-density lipoprotein and overweight were 56.17,p<0.001, 4.95,p<0.05,27.79,p<0.001 respectively. Exept hypertriglyceridemia is not standalone risk factore of VD, the rest every one have directly associativity with VD.Chinese population, hypertension is more prevalent than the other components of MetS. The increase in fasting blood glucose is listed on second seat. Third At simple hyperlipoidemia and high fasting glouse accompaniment with hyperlipoidemia,there have not different between two parts a begin.Thire p are up 0.05.At 6 week,HDL and BP have not different, p>0.05.But Tc,NO,ET,FBS,IN and LDL have different, P<0.05. At 12 week,every one have different, P<0.05 or P<0.01. From repeat analysis of variance we can find that high blood pressure, high fasting glouse , hypertriglyceridemia, high low-density lipoprotein and insulin have different at parts and parts (p<0.005), HDL-C, NO, ET-1 have different times(p<0.005), but they have not different at parts and times multiply parts.(p>0.005) From light microscope picture we can find that the endarterium of arteria carotis interna and arteria basilaris is not integrated,thire smooth muscle cells rank disorder,there are much lipid droplet infiltrate in smooth muscle at MS rat .and the endarterium of arteria carotis interna and arteria basilaris is integrated,thire smooth muscle cells rank order,there are small amounts lipid droplet in smooth muscle at hyperlipoidemia rat.From electron microscope we can find that The core of endothelial cell have had completely out of shape, there are much lipid droplet infiltrate in intracytoplasm whit MS rat, and The core of endothelial cell have had bigger but out line have had not fully ruinned, there are lipid droplet infiltrate in intracytoplasm whit hyperlipoidemia rat. The damage of the blood vessel texture and celluar structure with simple hyperlipoidemia rat is more lightly then MS rat. Hperlipoidemia accompaniment with high fasting glouse, the risk factor of VD convert more quickly to VD. Fourth From our investagation,according to age divided,>50 year,30-50 year,<30 year know every news of MS is 36.15%,27.00%,30.73% respectively; according to acadimic career divided,above bachelor's degree , between bachelor's degree and high school, below high school know every news of MS is 39.73%,29.49%,30.09% respectively. according to occupation divided, doctor ,nurse, administration and rear service know every news of MS is know every news of MS is 29.34%, 28.26%,14.77% respectively.Conclusion First This study is to prove the contribution of between the number of the risk factor in VD and the relapse of VD, the molar of survival.From our investigation we can find the number of VD risk factor is littler,the relapse of VD is lower and the meso-live time is longer.Becouse of MS part have more risk factor then simple stroke part,the meso-live time of MS part is shorter then simple stroke part meso-live time, and then their score of neurologic impairment is likely at first with stroke, but at relapse, score of neurologic impairment of MS part is highter then score of neurologic impairment of simple stroke part.They have significant deviation. It needs us to think highly of to the change of blood constituent and do some interfere in. Second Our data indicate that Chinese people living in urban regions with abnormal parameters of MetS have increased risks for CHD, stroke, and PAD. In Chinese population, hypertension is more prevalent than the other components of MetS. The increase in fasting blood glucose is listed on second seat. In order to prevent, recognize and treat MetS, we should develop effective public health strategies to control the hypertension and the increased fasting glucose and other abnormal parameters. Third This study selected hyperlipemia rat and hyperlipemia accompaniment whit high fasting glouse to observation thire different in blood vessle endothelium fomulative and blood consitituent. At the end ,we find that The damage of the blood vessel texture and celluar structure with simple hyperlipoidemia rat is more lightly then MS rat. Hperlipoidemia accompaniment with high fasting glouse, the risk factor of VD convert more quickly to VD.So we presume when there are many risk factor of VD to exist with one the damage of the blood vessel texture and celluar structure is not only every plus each other but they interact damage each other. In spite of we have not accurate date about they interact damage each other, but the mode of they interact damage each other have existed. It call attention to us do a lot of work in care and treat at MS. Fourth The study tells us the recognition about MS in medical worker is lesser. we suppose the recognition about MS in common crowd is least. The damage of MS is more and more severity, it need us learning new knowledge in time and education to public croed, making the concept of MS interiorize and downwards the incidence of VD from base.