Association Of Genetic Variation Of The Transcription Factor 7-like 2(TCF7L2) Gene With Gestational Diabetes Mellitus

ObjectiveGenetic and epidemiological studies suggest an association between gestational diabetes mellitus and type 2 diabetes.Both are polygetic multifactorial disorders characterized by beta cell dysfunction and insulin resistance.Gene polymorphisms of the transcription factor 7-like 2(TCF7L2) gene have been reported to be associated with type 2 diabets mellitus.Our aim was to investigate whether common genetic variants that have previously been associated with type 2 diabetes or related phenotypes would also confer risk for gestational diabetes mellitus.MethodsIn 1140 unrelated pregnant Chinese women(493 women with gestational diabetes mellitus, 647 non-diabetic control subjects) we genotyped the transcription factor 7-like 2 rs290487, rs11196205 and rs11196218 using ligase detection reaction.ResultsThe CC,CT and TT genotype frequencies of TCF7L2 rs290487 position in Beijing residents were 16.02%,45.18%and 38.79%;And the frequency of GG and CG genotype of TCF7L2 rs11196205 position were 95.46%,4.54%;And the frequency of AAAG and GG genotype of TCF7L2 rs11196218 position were 6.66%,41.70%及51.64%.The CC,CT and TT genotype frequencies of the TCF7L2 rs290487 variant differed significantly between women with gestational diabetes mellitus and control women(18.75%,45.83%and 35.42%vs 13.95%, 44.69%and 41.36%,x~2=6.49,p=0.039).Homozygous(CC-genotype) and heterozygous (CT-genotype) carriers in gestational diabetes mellitus group were higher than those in non-GDM group(x~2=4.082,P=0.043).Compared with T-allele carriers,the CC-genotype carriers had a 1.23-fold(95%CI 1.021-1.962,p=0.042) increased risk of gestational diabetes mellitus.NO differences of the genotype and allelic frequencies at rs11196205 and rs11196218 were observed between the cases and the controls.ConclusionsThere were polymorphisms of the transcription factor 7-like 2 gene rs290487C/T,rs11196205C/G and rs11196218A/G in Chinese population from Beijing residents.Homozygous(CC-genotype) and heterozygous(CT-genotype) carriers of TCF7L2 rs290487 variant in gestational diabetes mellitus group were higher than those in non-GDM group.The TCF7L2 rs290487 variant is associated with an increased risk of gestational diabetes mellitus in Chinese women.