Study On Relationship Between Adult Insulin Resistance And Multiple Metabolic Disorders In Yanbian Area

Objective:To analyze the relationship between adult insulin resistance(IR) and multiple metabolic disorders in Yanbian Korean Autonomous Prefecture area.Methods:①Using a simple random sampling method,1,235 permanent residents selected in the Antu County of Yanbian were carried out an investigation from August 2005 to August 2006.All of subjects was selected after eliminating the cases suffered from serious abnormal metabolic disorders and the other organic diseases and knew the informed consent.②Using the home visit and health examination,the relevant informations for this study were collected in the selected communities and health centeres.③The investigators were trained, and it was standardized that the survey contents,operational procedures and methods,and the home visit and inquiries were performed in accordance with unified questionnaire (including the general information,past history and family history of cardiocerebral vascular diseases,etc.).④It was measured that the height,weight,waist circumference,hip circumference and blood pressure,etc.⑤The fasting vein blood(fasting for 12 h) was taken in early morning,and it was measured that the insulin,serum total cholesterol(TC), triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),blood glucose and other indexes.The fasting insulin(FIns) was detected by radioimmunoassay,and human IR was estimated by the homeostasis model assessment method(Homeostasis model assessment, HOMA),and blood lipids and blood glucose were measured by automatic biochemical analyzer.⑥The measurement data were examined by ANOVA test;the numeration data were compared with the Chi square test:the correlation between IR and metabolism relative index was analyzed by a simple correlation analysis and partial correlation analysis;the IR influencing factors were analyzed by the multi-regression analysis;HOMA-IR as the dependent variable and hyperglycemia,hypertension,dyslipidemia,overall obesity and abdominal obesity as independent variable were analyzed by the Logistic regression analysis; the variables were selected by BACKWARD,selected variables were significant level asα= 0.05 and deleted variables were'significant level asα=0.01.Results:Out of 1,235 cases,male was 450(36.4%) and avarage age was 50.7 years, female was 785(63.6%) and avarage age was 50.1 years.①The average level of systolic blood pressure(SBP),diastolic blood pressure(DBP),TC,TG,body mass index(BMI), waist height ratio(WHtR),fasting blood glucose(FBG) were progressively higher with the increases of age(P＜0.01),and the ages in FIns and HOMA-IR were not statistically significant.②In this study population,the proportion of IR,hyperglycemia,hypertension, dyslipidemia,overall obesity and abdominal obesity was 25.0%,14.4%,37.5%,23.8%, 34.5%and 61.3%,respectively.③After adjusting the influencing factors for ethnicity, gender and age,the mean value of SBP,DBP,TC,TG,BMI,WHtR,FBG and FIns increased along with the.increase of IR level(P＜0.01).The prevalence rates of hypertension, dyslipidemia,hyperglycemia,overall obesity and abdominal obesity increased along with the increase of IR level(P＜0.01).The frequency of IR patients with hypertension,dyslipidemia, hyperglycemia,overall obesity and abdominal obesity was 49.5%,32.4%,30.4%,68.0%and 82.5%,respectively.The proportion of patients suffered from two or over two kinds of abnormal metabolism increased along with the increase of IR level(P＜0.01).④After simple correlation analysis and adjusting influencing factors for ethnicity,gender and age,the SBP, DBP,TC,TG,BMI,WHtR,FBG and FIns was all correlated with IR(P＜0.01).After adjusting the influencing factors for ethnicity,gender,age and BMI,there were still significant differences in the TC,TG,WHtR,FBG and FIns.⑤It was accompanied IR that 18.8%of patients with one kind of abnormal metabolism,32.7%with two kinds of abnormal metabolism with IR,42.6%with three kinds of abnormal metabolism and 68.2%with four kinds of abnormal metabolism,respectively.In this study population,patients with only one kind of metabolic disorder of hyperglycemia,obesity,hypertension and dyslipidemia accompanied with IR were 43.8%,22.3%,7.7%and 2.6%,and one with two kinds of metabolic disorders of hyperglycemia and obesity,hyperglycemia and hypertension,obesity and hypertension,obesity and dyslipidemia,hyperglycemia and dyslipidemia,hypertension and dyslipidemia accompanied with IR were 52.1%,45.5%,31.7%,28.4%,22.2%and 14.3%,and one with three kinds of metabolic disorders of hyperglycemia,obesity and dyslipidemia,hyperglycemia,obesity and hypertension,obesity,hypertension and dyslipidemia,hyperglycemia,hypertension and dyslipidemia accompanied with IR were 61.1%,48.8%,37.5%and 33.3%,respectively,and 68.2%of cases with four kinds of metabolic disorders accompanied with IR.⑥The results of multifactor analysis showed that IR was closely related with hyperglycemia,hypertension,dyslipidemia,overall obesity and abdominal obesity.Conclusion:①The prevalence of IR and common metabolic disorders in the general population is relatively high in Yanbian area;②The insulin resisters with common dysbolism are ubiquity,and the proportion of population with over two kinds of dysbolism increases along with the increase of IR level;③The frequency of IR increases significantly along with increase of dysbolism composition,and of different metabolic disorders and its different compositions with IR is different;④IR is clo(?)ely related with hyperglycemia, hypertension,dyslipidemia,overall obesity and abdominal obesity.