The Establishment Of Diagnosis Model Of Early Gastric Cancer

Gastric cancer (GC) is one of the most common malignant neoplasms in digest systerm worldwide.It is very important to find GC early for the curative effect of GC.The rate of the diagnosis of the early GC is much lower in our country.So it is very important to go a further study of the different change of the molecular and gene in the precancer lesion and GC tissues. the initial stated more than 100 kinds of genes and the development of gastric cancer, gastric cancer found that some of the Material. However, the clinical status is: Most patients in the treatment of advanced gastric cancer, the effect of poor. Early gastric cancer patients through surgery, the 5-year survival rate can reach 50%, while patients with advanced gastric cancer of the five-year survival rate of only 3-5 percent. Early diagnosis of gastric cancer is still far from solving problems. For gastric cancer patients how to solve the problems of early diagnosis? We believe that: Only by establishing the early diagnosis of gastric cancer model we can achieve this goal.About the human genome by about 100,000 different genetic composition, the selective expression of these genes determine the body throughout the life course, the changes in gene expression in a biological mechanism controlling the centre. Changes in gene expression is the most fundamental changes, the most sensitive to changes in the body reflects the characteristics of a particular phase of life. Gastric cancer is a combination of anti-cancer gene involved in cancer gene, multi-stage multi-channel synergies, making gastric progressive development of precancerous changes to the further development of gastric cancer to such an evolutionary process. Normal gastric mucosa precancerous changes to the process of gastric cancer and precancerous changes to the course there are differences in the characteristics of gene expression, to identify these genes and clarify these changes in gene expression and development of gastric cancer at different stages of the relationship between the law and its further study Precancerous lesions and gastric cancer gene to change the molecular differences, screening high-risk groups will help determine the molecular biology of indicators to improve the early diagnosis of gastric cancer. At present, there are studies show that cancer gene c-met, APC tumor suppressor gene and apoptosis suppressor gene bcl-2 in gastric cancer and precancerous lesions in the gastric mucosa have abnormal expression of these gene changes that occurred in the early gastric cancer, fewer reports of domestic And some conclusions are controversial. To this end, the joint testing on the c-met, APC and bcl-2 in gastric cancer and gastric precancerous lesions of the expression, come to the conclusion that the deactivation of the APC gene, bcl-2 and c-met gene expression In the incidence of gastric cancer, promote development in the role of the stomach severe dysplasia mucosa for APC, bcl-2 and c-met gene contribute to the detection of early diagnosis of gastric cancer.Reference to the U.S. Gastrointestinal Association, proposed more than 45 years of age or dysplasia patients should periodically for gastroscopy. With mild symptoms of patients under the age of 45 under doctor's diagnosis and treatment of experience, not mandatory. In the high incidence of Helicobacter pylori, should check in advance the appropriate age. Precancerous lesions of the regular stomach cancer GASTROSCOPY contribute to the early detection, 5-year survival rate from 10% to 50%. Endoscopy is the most important early diagnosis of gastric cancer, the most direct way, the diagnosis is recognized as the gold standard for early gastric cancer, gastric cancer is early diagnosis rate of 90 percent. But gastroscopy expensive, but also bring a lot of suffering to patients. This study was a single item detection and testing of joint projects found that when compared to PGⅠ<30μg / l or PGR <3.0 or GS> 95 pg / l and HP (+), the sensitivity and specificity than ideal, that is detected by the above target For the early diagnosis of stomach cancer has provided a superior gastroscope and so on the exact reasonable and inexpensive means of detection. However, these indicators of EGC lack of specificity. Therefore, the urgent need to develop cheap, comfortable and suitable for gastric cancer screening method. At present, there are potential clinical value of the serum precancerous lesions or gastric cancer detection methods are being explored in the study, this will be a breakthrough in early diagnosis of EGC. In recent years studies have shown that as cell metabolites and the biological activity of an important factor, lysophosphatidic (lysophospholipids, lyso-PLs) such as the LPA, LPC, S1P and SPC, such as in the development of tumors and plays an important role. This paper applications in the international community has just emerging group of lipids in the blood approach to the human body's biological activity lysophosphatidic molecule identification and quantitative analysis. That of 18:1 - LPC and 18:2 - LPC and combined the two to detect gastric cancer specificity and sensitivity are higher, unsaturated LPC may be stomach cancer early screening of potential markers. This study aimed at the establishment of the Chinese model of early diagnosis of patients with gastric cancer. The study will in genomics and proteomics, for the early diagnosis of the tumor on the way to open up a brand-new. With the traditional method of testing tissue samples compared to biological molecules such activity lipid metabolism of functional cell research as more conducive to the early diagnosis of tumors. Through these secretion of bodily fluids to small changes in the molecular level, can be timely and accurate detection of tumors in the early metabolic abnormalities.