Liver Depression And Spleen Deficiency Syndrome Based On Data Mining Research

Traditional Chinese Medicine (TCM) is among the oldest medical sciences in history. Along with its several thousand years of development, TCM has evolved into a range of medical practices with a massive accumulation of information presented today as medical literature, observation notes, original test data, testimonies and legendary stories. Because traditionally TCM diagnosis was based on observation rather than laboratory tests, subjective diagnosis on similar symptom has been very common due to lack of normalized standards.One essential and critical step to modernize TCM is to normalize diagnosis with objective and scientific standards. The foundation of this is to establish tools to standardize the way we objectively perceive from symptom studies. It is apparent that a break through in methodology on symptom study to generate standardized parameters will certainly facilitate the efforts towards the modernization of TCM.Modern technology such as data mining has demonstrated that prediction and evaluation of possible pattern of information can be obtained by computer assisted statistical analysis methods. The advance in such technology has enabled an objective analysis based on collections of variety of information. If it approves its efficacy on TCM symptom studies, standardization of diagnosis can be achieved. In this research, statistical analysis methods of data mining technology have been introduced as a tool to massively interpret data from a variety of TCM literatures. The approach of this research is to examine the technology to discover , evaluate and predict potential patterns of information based on frequency of occurrence and patches of association from a variety of data embedded in both ancient TCM literatures and current medical journal articles. Liver Depression and Spleen Deficiency Syndrome (LDSD) is chosen as a model syndrome of study. Any shared characteristics can then form essential elements for an objective assessment to the model illness. Therefore a standardized diagnosis for LDSD can be achieved. The research not only lights up some insides for better understanding of LDSD , it also opens a path to a powerful method for symptom/syndrome studies in TCM.Research Objects1,Using Liver Depression and Spleen Deficiency Syndrome and Liver Depression Syndrome as dataset and perform data mining analysis based on related articles from Dictionary of Traditional Chinese Medicine;2,Using Liver Depression and Spleen Deficiency Syndrome as dataset and perform data mining analysis based on related articles from journal articles dated from 1978 to 2007MethodsApply statistical analysis methods of data mining on collected medical literatures for Liver Depression and Spleen Deficiency Syndrome and Liver Depression Syndrome to look for general rules for diagnosing Liver Depression and Spleen Deficiency Syndrome. The analysis may include frequency analysis, factor analysis, and discriminant analysis.Researcher results1. Ancient literature1.1 The data mining of literature about Liver Depression SyndromeFrequency analysis: Results from this analysis suggest aggravation and anxiety are the most common reason; hypochondriac region distending pain, abdominal stuffiness and vomit are the most common symptoms; xiaoyaosan decoction and baishao, chaihu, xiangfu are the most common treatment; taut pulse, deep pulse, sluggish pulse are the most common pluses; hyperthymia and using the warm medicine wrongly is the main taboo and the disease happens to females mostly.Factor analysis: Disharmony between Liver and Stomach, Disharmony between Liver and Spleen and heat stagnation are most common compound visceral syndromes.1.2 The data mining of literature about Liver Depression and Spleen Deficiency SyndromeFrequency analysis: there are more than 10% symptoms appeared as hypochondriac region distending pain, emmeniopathy, alternate attacks of chill and fever, poor appetite, fever, weakness, abdominal stuffiness, hectic heat, dysphoria and bitter taste in mouth. Factor analysis: Disharmony between Liver and Stomach, Disharmony between Liver and Spleen, heat stagnation and syndrome of endogenous heat due to yin deficiency are most common compound visceral syndromes.Chi-square test: symptoms such as emmeniopathy, alternate attacks of chill and fever, poor appetite, fever, weakness appeared more frequently in Liver Depression Syndrome; and symptoms such as abdominal stuffiness, constipation, and headache appeared more frequently in Liver Depression and Spleen Deficiency Syndrome.2 The data mining of current literature about Liver Depression and Spleen Deficiency Syndrome2.1 The data mining of clinical literatureFrequency analysis: abdominal stuffiness, taut pulse, greasy in white coating, poor appetite and diarrheas are top 5 symptoms in all Liver Depression and Spleen Deficiency Syndrome in the diseases we studied, just in different orders. Chi-square test: weakness , sallow yellowness , hypochondriac region distending pain, depression is significant for the diagnosis of liver diseases; poor appetite, gastralgia is significant for the diagnosis of stomach diseases; diarrhea, abdominal stuffiness is significant for bowel diseases; depression, sluggish pulse is significant for depression.Discriminant analysis: Discriminant analysis is used to set up equations for each syndrome, estimated how correlative the symptom is according to the coefficients of the equations.2.2 The data mining of literature animal experimentsHPA is closely related to the functions liver in TCM , the change of neurotransmitter in hippocampus is opposite to BLA, especially in CA1 and BLA. Neuropeptide increase while NGF and immunity system decrease.the syndrome modesl of Liver Depression and Spleen Deficiency Syndrome have been demonstrated to be successful, and the regulative effect of Xiaoyaosan shows regional-selective, time-dependent and double-way (up and down) regulative characterization.Conclusions 1. Some new or neglected knowledge of TCM could be found out by data mining technique.2. According to the Ancient literature searched, symptoms of Liver Depression and Spleen Deficiency Syndrome and Liver Depression Syndrome are similar basically. Disharmony between Liver and Stomach, Disharmony between Liver and Spleen, heat stagnation and syndrome of endogenous heat due to yin deficiency are most common compound visceral syndromes.3. Liver Depression and Spleen Deficiency Syndrome appears some similar symptoms in different diseases, which means every syndrome in TCM gets particular character.4. Each disease presents own traits, its necessary to establish diagnosis criterion considering both disease and syndrome.5. Discriminant analysis is used to set up equations for Liver Depression and Spleen Deficiency Syndrome in liver diseases, stomach diseases, bowel diseases and depression. They would be helpful to the standardization of the syndrome.6. The syndrome modesl of Liver Depression and Spleen Deficiency Syndrome have been demonstrated to be successful, and the regulative effect of Xiaoyaosan shows regional-selective , time-dependent and double-way (up and down) regulative characterization.