Yupingfengsan Immune Mechanism Of Action

In traditional Chinese medicine, Lung is the most important organ of qi, which has close relationship to the surface of body. The YiQiGuBiao method can strengthen the body surface resistance by improving the qi in spleen and lung. In clinic, this method is often used either in qi deficiency of spleen and lung or the instability of surface defensive function. YuPingFengSan is the present prescription of YiQiGuBiao method. It affects on the immune system and has a certain effect. In this research we mainly study on the mechanism of the prescription and the YiQiGuBiao method.In the experiment we observed the function of YuPingFengSan total polysaccharide on immune regulation and the prescription composing meaning of each polysaccharide. Also we observed the effect of total polysaccharide on mice immune function during different administration or periods, and the absorption in intestine. We discussed its effect on intestinal and respiratory mucous membrane immunity, through the immune deficiency model caused by cyclophosphane, TPN and cold. The research took YunZhi polysaccharide the immunity enhancer as control, to discuss the speciality on mucous membrane immune enhancement.Results: 1. The polysaccharide in YuPingFengSan is the main substance of immune regulation, and different polysaccharide in the prescription has different effect on mice immunity. 2. The polysaccharide in YuPingFengSan has unique mechanism and effect on intestinal mucous membrane immune system. The function is mainly produced by intestine progress itself and influence the respiratory mucous membrane, also it affects on specific and non-specific immunity of the whole body. 3. The polysaccharide in YuPingFengSan affects various indes and points in mucous membrane immunity, either by pre-administration or curing administration. Especially in the pre-administration way, the body immune faculty is kept in a high level "stability", which may be helpful to defend the invasion of outside factors.The intestinal progress of YuPingFengSan polysaccharide can activate the whole mucous membrane immune system to enhance the respiratory immunity. The enhancement of mucous membrane immunity is the key point in YiQiGuBiao method. This research discussed on the clinical use of YuPingFengSan and its related traditional Chinese medicine theoretic, also it suggested new researching direction of the polysaccharide drugs.