Glutamine Dipeptide On The Intestinal Mucosa And Intestinal Barrier Function In Post-traumatic And Molecular Mechanisms Series Study

Traditional parenteral nutrition leads to bacterial translocation. The effects of alanyl-glutamine dipeptide (Ala-Gln) enriched parenteral nutrition solution on intestinal mucosa or gut barrier were investigated. The moderate operation stress was induced by 60% resection of small intestine. Thirty rats were divided into three groups: Chow group (n=10) received standard rat chow. PN group (n=10) received traditional parenteral nutrition solution only, and Ala-Gln group (n=10) received glutamine dipeptide enriched nutritional solutions (3% Ala-Gln). Rats were maintained on their respective diets for 7 days. Results: Chow group and Ala-Gln group maintained serum glutamine concentration, villus height and mucosal thickness. While bacterial translocation rates in Chow group and Ala-Gln group were 20%, In PN Group was 70%. Results demonstrate that Ala-Gln enriched nutritional solutions maintains intestinal adaptation and gut barrier function after massive intestinal resection.