Accelerate Orthodontic Tooth Movement Experiments Explored The Mechanism Of Orthodontic Tooth Movement

The present investigation consists of two parts. The first one concerns the experimental study of enhancing movement rates of orthodontical teeth, and the second deals with the movement mechanism of orthodontical teeth based on the periodontal circulation, enzyme activities and their distributions observed after orthodontical treatment.In the first part, scanning and transmission electron microscopies were employed to observe the effects of PGS, V₀, and dexamethasone on periodontal tissue, in addition to routine histology methodolgies. Besides, PGE, and PGE, in rabbit periodontal tissue and blood pre—and-post orthodontal treatment were detected by radioimmunoassay in order to provide basis for farther probing into the relationship between PGS and orthodontical movement and these studies are as follows:1. The relationship between different concentrations of PGE, and dental movement speed, periodontal tissue injury and repair were analysed under the equal orthodontical force, and it was observed that with increasing concentrations, the tissular osteogenesis and osteolysis appeared progressively active. Furthmore, dental movement speed was hastened, and tissue reaction and injury were gradually intensified. Under a specified condition, dental movement speed was significantly related to the concentrations of PGE, and the regression model of dental movement distance and concentrations were positive correlation.2. The effects of PGE, and PGE, on orthodontical tooth movement speeds were compared. In addition, the inhibitory role of dexamethasone in dental movement was observed. The results indicate that PGE,and PGE. of an equal concentration had insignificant influence on orthodontical tooth movement] speeds with basically the same histologies. On the contrary, as antagonist for PG, dexamethasone could effectively slow down dental movement speeds.3. The effects of PGE₁, E₂, V₀ and dexamothosane on periodontal tissue were observed light and electron microscopically and it was found that the above-mentioned drugs had different roles in histological...