| FDFI shows that it has effects against aconitine to induce arrhythimas and decrease the incidence of CaCl2, that induce ventricular fibrillation in rats. The doses of ouabain requlred to induce ventricularpremature beats, cardiac arrest in guinea pigs were markedly increased by prior administration of FDP I. when treated with FDP I the BaCl2-arrhythmias in rats changed immediately into sinus rhythm and lasted more than 12 min. FDP I ip 20-40mg/kg also decreased the incidence of chloroform-induced ventricular fibrillation in mice. The incidence of ventricular premature beats and ventricular tachycardia yielded by reperfusion of left coronary occlusion in rat reduced significantly by iv FDPI 20 mg/kg.In an isolated heart model connected to a recirculating nonpulsatile circuit, FDP I 20 umol/L could prevent occurrence of reperfusion-induced arrhythmia of rabbit's heart. FDP I produced a bradycardia in vitro and vivo. |
