Moxibustion Functional Regulation Of Gouty Arthritis Synovial Cells In Mice

Objective To investigate the regulation of synovm cell function and its mechanism in gout mouse with moxibustion. Methods The gout mouse were treated respectively with indomethin and moxibustion; the swelling of joint was measured by drainage; the number of MSU and pathological feature were detected through HE colouring; The change of concentration of TNF- a ? IL-2, IL-4, IL-12 were evaluated by ELISA; the exppression of HSP70 detected by immunohistochemistry. Results: The swelling was alleviative the number of MSU was fewer after moxibustion treatment taken in gout mouse; the amount of TNF-a in joint synovm was decreased while IL-2 and IL-12 increase after 3 courses(21days) treatment with moxibustion ; the expression of HSP70 was enhanced by moxibustion. Conclusions: Wheat-moxibustion can alleviate the swelling apparently which is relation to regularting the mount of cytokine joint synovm and enhacing the expression of HSP70.