The Relationship Between The Serum Resistin Levels And Cardiovascular Diseases In Elderly Men: A Cross-sectional Study

Objectives: to determine the relationship between the serum resistin levels andcardiovascular diseases in elderly men.Material and methods:843men (aged60and older) were enrolled. The body height,body weight and blood pressure (SBP and DBP) were measured. The serum levels ofresistin, Cystatin-C, CRP, NT-pro-BNP, lipid profiles (TC, TG, LDL-C and HDL-C),glucose, Cr were determined and GFR was calculated. The correlation analyses wereperformed with these continuous variables. The multiple linear regressions wereperformed with the serum levels as independent variable. Then, the whole corhortwas divided into groups according to cardiovascular diseases (MtS, hypertension,DM, obesity, CHD, PAOD, CHF, CKD and AF). The serum resistin levels werecompared between the groups with these disease and the control groups withoutthese diseases. The binary logistic regressions were preformed with these diseases asindependent variables.Results:1. In the whole corhort, the serum resistin levels were negatively correlatedwith eGFR (p<0.001), DBP (p<0.05), TC (p<0.001), LDL-C (p<0.001), HDL-C(p<0.001); were positively correlated with age (p<0.001), SBP (p<0.05), Cr(p<0.001), Cystatin-C (p<0.001), TG (p<0.001), CRP (p<0.001) and NT-pro-BNP(p<0.001). There was no correlation between resistin and BMI (p>0.05) and(p>0.05). The multiple linear regression analysis showed that Cystatin-C, CRP,NT-pro-BNP and HDL-C were independently correlated with resistin;2. The serumresistin levels in patients with MtS were significantly high than those in respectivecontrol groups. The logistic regression analysis showed that resistin was the riskfactor of MtS after controlling the age, however, this relationship disappered aftercontrolling the serum CRP level;3. The serum resistin levels in patients withhypertension, DM and obesity were not significantly high than those in controlgroups.4. The serum resistin levels in patients with CHD and PAOD weresignificantly high than those in control group. The logistic regression analysisshowed that resistin was the risk factor of CHD after controlling the age, however, this relationship disappered after controlling the serum CRP level. After controllingthe age and CRP respectively, the resistin level was not the risk factor of COPD;5.The serum resistin levels in patients with CHF were significantly high than those incontrol groups. The logistic regression analysis showed that resistin was not the riskfactor of CHF after controlling the age and CRP level respectively;6. The serumresistin levels in patients with AF were significantly high than those in control group.The logistic regression analysis showed that resistin was the risk factor of AF aftercontrolling the CRP, however, this relationship disappered after controlling the serumage;7. The serum resistin levels in patients with CKD were significantly high thanthose in control group. The Cystatin-C was independently correlated with resistin inboth CKD group and control group. The logistic regression analysis showed thatresistin was the independent risk factor of CKD after controlling the age, CRP, andmedical history (CHD, PAOD, CHF, CKD and AF).Conclusions:1. Cystatin-C, CRP, NT-pro-BNP and HDL-C were independentpredictors of resistin;2.The resistin was correlated with MtS, CHD, PAOD and CHF.These relationships might be mediated by CRP;3. The resistin was correlated withAF. There might some factors other than inflammation explaining the relationshipbetween the resistin and AF;4. The resistin was the independent risk factor of CKD;5.The present study was a cross-sectional study and the results were just preliminary,which needed to be confirmed in a larger, randomised, controlled follow-up study.