The Resistin Levels Of Patients With Chronic Renal Failure And The Clinical Significance

Objective: The current study was performed to determine the levels of serum resistin of patients with chronic renal failure (CRF) , examine the possible correlations with renal function ,insulin resistance and the risk factors of cardiovascular disease ,and explore the possible clinical significance in CRF patients.Method:The study was performed on 44 conservatively treated CRF patients and 13 haemodialysis patients,and 23 age- and gender-matched healthy volunteers as control group. Serum resistin levels were measured by sandwich enzyme-linked immunosorbent assay(ELISA). We collected clinical data of every group,such as sexuality, age,fasting insulin, fasting blood glucose, fibrinogen,creatinine, C-reactive protein, and calculated body mass index, waist to hip ratio, body fat percentage,insulin resistance index, glomerular filtration rate and so on.Result:1. Serum resistin levels were higher in cases than in normal controls(P<0.01 ) .Serum resistin levels had positive correlation with serum creatinine(r=0.863,P<0.01)and negative correlation with estimated glomerular filtration rate(r=-0.802,P<0.01).2. Serum resistin levels of haemodialysis patients had no significant change after hemodialysis(P>0.05 ).3. Serum resistin levels of CRF patients had no correlation with fasting blood glucose,fasting insulin and insulin resistance index(P>0.05 ).4. Serum resistin levels of CRF patients had significant correlation with risk factors of cardiovascular disease,such as C-reactive protein, fibrinogen, uric acid (correlation coefficients were:r=0.444,P<0.01;r=0.451,P<0.01;r=0.324,P =0.032,respectively ).5. Serum resistin levels of CRF patients had no correlation with blood pressure,blood fat, age and obesity(P>0.05 ). Serum resistin levels between men and women patients had no significant difference(P>0.05 ).6. In Multiple stepwise regression analysis, estimated glomerular filtration rate and C-reactive protein correlated with serum resistin(b'=-0.736,P<0.01;b'=0.230,P=0.015).Conclusion:1. Serum resistin levels of CRF patients increase compared with normal controls ,which is possibly associated with impaired renal function.2. Haemodialysis does not eliminate resistin.3. Serum resistin of CRF patients possibly have no association with insulin resistance.4. Resistin is associate with risk factors of cardiovascular disease (C-reactive protein, fibrinogen, uric acid) in CRF patients .5. Serum resistin of CRF patients have no association with blood pressure,blood fat and obesity; gender and sexuality have no significant influence on resistin levels of CRF patients.6. Both stimated glomerular filtration rate and C-reactive protein are proved to be robust predictors of serum resistin in CRF patients.