A Clinic Study Of The Method Of Supplementing Qi And Nourishing Yin, Promoting Blood Flow And Eliminate Phlegm To Treat CHD

Objective:The aim of this study is to observe the changes of symptoms, ECG changes using Guanxinping, compared with "xinkeshu" as positive control in the treatment of Coronary heart disease (CHD).Also oxidative stress index NO,SOD, inflammatory reaction is the most important index to be observed.Method:1.A11of the observations come from Jiangsu TCM hospital Cardiovascular in-patient Department. The total number of the observations is160. Among them80observations in treating group were treated with guanxinpin, while the rest as control group were treated with xinkeshu in one month. Symptoms, ECG, blood fat and endothelium function index was observed. Safety and clinic efficacy was also evaluated by using both therapeutic and control group for one month.. NO use NR(nitrate reductase) method to analysis, SOD use XO (xanthine oxidase) method to analysis。2. Statistical analysis:Descriptive statistic analysis Qualitative index use percentage and Quantitative index use mean and standard deviation. In evaluating significance, the Chi-square analysis was used in Quantitative data and "t" analysis was used in evaluating qualitative data. Statistical analysis was done with SPSS software.Result:1. In clinic efficacy:Both therapeutic and control group can alleviate patients symptoms, of which the therapeutic group is more evident (P<0.05). Both therapeutic and control group can decrease angina pectoris frequency and duration (P<0.01), of which the therapeutic group is more evident (P<0.05).2. In ECG efficacy:Both therapeutic and control group can improve ECG efficacy, but there is no difference between them.(P>0.05). Both therapeutic and control group can change ischemic ECG efficacy, but there is no difference between them.(P>0.05).3. In TCM symptom efficacy:Both therapeutic and control group can improve TCM total symptoms, of which the therapeutic group is more evident (P<0.05). Both therapeutic and control group can improve each TCM symptoms, of which the therapeutic group is more evident (P<0.05). Both therapeutic and control group can improve grading of illness, of which the therapeutic group is more evident (P<0.05).4.1n endothelium functions:The therapeutic group can elevate NO,6-keto-PGF1αand NOS (P<0.05) and can also lower ET and TXB2(P<0.05) after treatment. It seems that the control group can elevate NO,6-keto-PGFlaand NOS and lower ET,TXB2after treatment. But it has no statistical significance. The therapeutic group can improve each therapeutic index compared with control group and has statistical significance(P<0.05).5. In oxidative stress and inflammatory reaction:The therapeutic group can elevate SOD and GSH (P<0.05. P<0.01). And can also lower hs-CRP (P<0.05). The control group can elevate SOD (P<0.01), But there is no difference between the two groups.(P>0.05).Conclusion:Guanxingping which presents the method of supplementing qi and nourishing yin, promoting blood flow and eliminate phlegm to treat coronary heart disease has positive curative effect and can be used in clinic treatment, the therapeutic mechanism is to protect VEC and to improve EDF,blood fat dysfunction, antioxidation and antiinflammatory...