Prevalence Of COPD And EBC Detection In Estimating Of Airway Inflammation

Objective:To investigate the prevalence of chronic obstructive pulmonary disease(COPD)and its major risk factors in Haokou, Hubei province. Evaluate the association of exhaled breath condensate (EBC),induced sputum and serum biomarker changes with the COPD patients in stable stage. Estimate the airway inflammation of COPD patients with detection the interleukin-8, leukotriene B4,8-iso-PG,tumor necrosis factor-aand leptin in serum, induced sputum and exhaled breath condensat.finally, we studied the association between rs4673 (C242T) haplotypes of gene coding p22phox which is one of important submit of NADPH oxidase and the susceptibility of COPD.Methods:Using the entire group random sampling method, we select residents of 40 years of age or older living in 15 villiage of Haokou, carry on the questionnaire survey, the physical and lung function examination, with the results of lung function examination as the diagnoses basis for COPD.Results:A total of 1554 subjects were enrolled in this study. The overall prevalence of COPD was11.13%, of which, the male prevalence was 13.57%, the female prevalence was 7.44%, the male prevalence was significantly higher than the female prevalence.Of the subjects with COPD,137 subjects (78.8%)had COPD gradeⅢor worse. Single-factor non—conditional Logistic regression analysis showed that the following factors were statistically associated with the occurrence of COPD:gender, age, cigarette smoke, cooking with raging fire, outdoor air pollution, low BMI. Multi—factor non—condjtional Logistic regression analysis showed that the following factors were associated with the occurrence of COPD:age, gender,active smoking. Thelever of inflammation and oxidative stress marks are higher in COPD stable patients than in healthy controls,that indicated these COPD patients in stable stage suffered airway inflammation.EBC may be helpful in monitoring airway inflammation in COPD,but the testing procedure should be standardizing. The polymorphisms of the C242T didn't relate to the of COPD.Conclusion:The prevalence rate of COPD in village of hubei province is high, COPD is a major public health problem in China and call for more efforts to preventing measures and regular treatment of COPD.