The Pharma Codynamics Study On Liver Lesion Treated By Pirorhia Compsitae Capsule

Viraus hePatitis,alcoholic hePatitis,drug hePatitis and other liver diseases are frequently encountered diseases now in China and in the world. Especially, the morbidity of virus hepatitis is increasing year by year. All kinds of liver dieases can cause the same pathologic chang which is denaturation and mecrosis of liver cell—liver lesion is very important.The compound prescription of Chinese medicinal herbs have significant therapeutic effect in respect of treating liver lesion.Finding the active ingredients in compound prescription and studying by the method ofpharma codynamics and toxicology on the instructionof the theory of traditional Chinese medicine is more important.This can help to approve the regular rule and effect mechanism of compound prescription,to make the pharmaceutis technology more better and to make standard,safe,quality criterion which can accelerate the mordernized and international steps of compound prescription.The effective part in Picrorhiza compositate capsule can treat liver lesion.It is extracted and refine from Picrorhiza and Paeoniflorin.The chemical ingredients in this effective part are Picroside and Paeoniflorin.The paper elaborate the symptoms, the etiology and pathogenesis of the liver lesion.The paper also elaborate the principle of picrorhiza compositate capsule and the curing mechanisms.In experiment,the experiment studied on D-Galctose caused the acute liver damage,cured the alcoholic liver injury and enhance the body immunity function.The experimental conclusions prove that the pierohiza conpositae capsule can decreaseALT level and AST activity significantly,while ehance SOD activity and decrease MDA content in hepatic. The pierohiza conpositae capsule also can enhance non-specific cell immunity and flood.The Picrorhiza conpositate capsule can improve the pathological changes of liver tissue and liver cell ultrastructure.HE section showed that the Picrorhiza compositate capsule treatment the D-Galctose caused the acute liver damage was better than alcoholic liver injury on cell swelling.Ultrathin section of electron microscopy showed that the Picrorhiza compositate capsule treatment the D-Galctose caused the acute liver damage was better than alcoholic liver injury on improve the structrue of mitochondria,bile duct and rough endoplasmic.