A Mechanism Study On Stabilizing The Intraocular Pressure And Protecting The Optic Nerve With Yi Yin Ming Mu Mixture

Objective:To treat the glaucoma in middle and advanced stage with the method of YiQiYangYinKaiQiao and to study the mechanism of stabilizing the intraocular pressure and protecting the optic nerve with it.Methods:1.Experimental study:The plasma ET,NO,retinal SOD,MDA and Glu of the acute high intraocular pressure rats that treated with Yi Yin Ming Mu mixture were observed.2. Clinical study:The clinical therapeutic effect was observed by means of comparing the changes of visual acuity, visual field and intraocular pressure, before and after treatment.Results:1.Yi Yin Ming Mu mixture can effectively improve the activity of SOD, reduce the content of MDA, Glu, ET and NO of the acute high intraocular pressure rats.2. The curative effect of Yi Yin Ming Mu mixture in treatment of glaucoma in middle and advanced stage is obvious, with a total effective rate was 94.87%. Conclusion:l.The therapeutic effect of Yi Yin Ming Mu mixture in treatment of the patients with glaucoma in middle and advanced stage is identified.2.Yi Yin Ming Mu mixture can stablize the intraocular pressure and protect the optic nerve probably through clearing free radical, improving the anoxia tolerance, modifying microcirculation, restraining the releasing of Glu and reducing the content of ET.