Genetic Susceptibility, Environment Risk Factors And Their Interaction In Esophageal Cancer

Esophageal cancer (EC) is one of the most common tumors of human being. China is the country with the highest EC incidence and mortality rate in the world. Epidemiology studies indicated that environment factors were the main causes of EC. And one point is worth mentioning, only a few people exposed to the carcinogens suffer from EC, and the genetic susceptibility probably accounts for it. With the development of tumor molecular epidemiology, EC has been considered as multifactor related disease, and those with special genetic predisposing traits are likely to have greater risk from carcinogens. However, up to now, it is still not quite clear that how the genetic susceptibility to EC and the relationship between susceptibility and environment risk factors play in the cancer.For comparison, two hospital-based case-control studies in Linzhou and Xi'an were carried out to investigate the environment risk factors of EC. PCR and RFLP were employed to detect genotypes of CYP1A,GSTμ,CYP2E1 and NAT2. Uni- and multi-variate analysis were used to meseaure the effect of environment risk factors and saturated model and collapsibility model were...