Case-control Study Of The Risk Factors To Esophageal Carcinoma

Objective To find the main behavior risk factors in the area of higher incident rate of esophageal carcinoma(EC) of shanxi province, at the same time, to study the relationship between personality,the genetic polymorphisms of CYP2E1 and esophageal carcinoma, and the behavior-personality or behavior-gene interaction ,so as to provide evidences for making the integrated preventive measures and revealing etiological facter's mechanisms for esophageal carcinoma in the higher accident place.Methods This study was carried out using a case-control method, which the case group was collected from Shanxi Tumor Hospital from March to December in 2005,and the control group came from health people of community by typical sampling in taiyuan city. 60 Cases were correctly with same received and rejcted condition, and 199 controls were matched according to age,sex,and using 1:3or1:4 different rate. All subjects were investigated with same questionair and kartaier's 16 personality factors test(16PF), using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism test(PCR—RFLP). Statistics analysis was carried out by SPSS11.5 statistical package withχ2-test,t-test and pair-logistic regression analysis. Results 1. Analysis of multiple variables pair-logistic regression showed that smoking,highter temperature diet,speed of eat,drinking overnight tea,and drinking thin soap were the main behavior risk factors of esophageal carcinoma. Their OR(95%CI) respectively were 2.787(1.239~6.267),2.131(1.017~4.469),2.079,(1.019~4.241),1.084(1.030~1.141),2.704(1.759~4.156).2. Analysis of multiple variables pair-logistic regression showed that dominance and abstractedness were the main personality risk factors of esophageal carcinoma, Their OR(95%CI) respectively were 1.500(1.041～2.163),1.477(1.101～1.980).3. CYP2E1 have three kinds of genotype which were wild homozygote(A genotype),mutation heterozygote(B genotype),mutation homozygote(C genotype) .Frequencies of them were 53.33%,30.00%,16.67% in case group, and50.75%,34.67%,14.58% in control group respectively(χ2=0.494,P =0.781). Allele frequencies of C and T were 68.33%,31.67% in case group, and 68.09%,31.91% in control group respectively(χ2=0.003,P =0.960).4. Interaction analysis result :there was synergistic action between smoking and abstractedness (S=2.35, API=0.46, RERI=2.37).Conclusion Smoking ,highter temperature diet, speed of eat,drinking overnight tea,and drinking thin soap were the main behavior risk factors of esophageal carcinoma; Dominance and abstractedness were the main risk personality factors of esophageal carcinoma; We could't say CYP2E1 was the predisposing genes to esophageal carcinoma. Smoking and abstractedness had synergistic action in interaction.