| Purpose:The etiology of the worldwide incidence of hypospadias remains unexplained. Data from many Centers for disease control and our epidemic research suggest that maternal orgnaophosphorus (OP) -dichlorvos (DDVP)exposure may be an important risk factor. The development of the rat and human urethra shows significant similarities, so as to justify the use of the rat as a suitable experimental animal model. DDVP may act as hormones disturb directly or alternatively lowering androgenic hormone by unknown way. We describe the effects of DDVP on rat urethral formation rat and take androgenic hormone analysis of maternal rats. Furthermore , immunohistochemistry technology were adopted to explore what influenced in urethral and genital development of male rat. |
