Establishment Of Experimental Method For Pharmaco-dynamic Study Of Anticariogenic Natural Medicine

Dental caries is a multifactorial and chronic bacterial disease that involves the destruction of tooth hard tissue structure. It directly results from acid dissolution of the mineral phase of the teeth, the acid being produced by metabolism of dietary carbohydrates by oral bacteria in dental plaque. The current concept regarding cariogenesis is that a caries lesion, either clinically invisible or detectable, is the accumulation of numerous episodes of de- and remineralization, rather than a unidirectional demineralization process. If the remineralization progresses predominantly over periods, the demineralized lesion is to be reversible. Therefore, remineralization is an important natural repair process, countering cariogenic challenges. As a chemotherapeutic agent to combat dental caries, fluoride occupies a unique position. Although Fluoride's anti-caries efficacy i.e., inhibition of tooth demineralization, promotion of incipient lesion remineralization, is well-proven, there are a number of reasons to continue to seek alternative, effective non-fluoride anti-caries agents. Our previous study has suggested that Galla Chinensis and Nidus Vespae had...