Transcatheter Closure Of Secundum Septal Defect By Amplatzer Occluder And Realated Study

Part one: Comparison of efficacy and cost between transcatheterand surgical closure of secundum atrial septal defectObjective: To compare the efficacy, safety and cost between Amplatzer occluder and surgical closure of secundum atrial septal defect. Methods: According the same inclusion criteria, 273 patients with secundum atrial septal defect were treated by surgical closure (159 cases) or transcatheter closure with Amplzater occluder (114 cases). In surgery group there were 51 male patients, 118 female patients with median age of 20.7 ±15.1 years. In transcatheter closure group there were 46 male patients, 68 female patients with median age of 25.4±16.1 years. The median size of atrial septal defect of surgery group and transcatheter closure group was 16.46±5.04 mm and 18.87 +6.06 mm respectively ( P=0.01) .Results: the procedural attempt successes rate was 100% for surgery group and 96.94% for transcatheter closure group(P=0.007) . Residual shunt rate of surgery group and transcatheter closure group was 1.2% and 2.7% respectively (P>0.05) . Total complication rates both of surgery group and transcatheter closure group were 15.12% and 2.7% respectively (P<0.05), major complications rates both of groups were 2.5% and 0 respectively (P<0.05), minor complications rates both of groups were 13.2% and 2.7% respectively (P<0.05). No patient need blood transfusion in transcatheter closure group whereas 66 patients accepted blood transfusion which mean volume was 577 ± 191 ml and there was a significant negative linear correlation between ages and blood transfusion volumes (r=0.53, P<0.05) in surgery group. The cost of surgery group and transcatheter closure group...