Clinical Study And Analysis Of Risk Factors Of Capillary Leak Syndrome Related To Cardiopulmonary Bypass In Children Underwent Cardiac Operations

Capillary leak syndrome (CLS) is a rare condition characterized by unexplained episodic capillary hyperpermeability due to a shift of fluid and protein from the intravascular to the interstitial space. This results in diffuse swelling, hypovolemic shock and may result in significant morbidity and mortality. The syndrome was first reported by Clarkson in 1960.After cardiac operations on children we can find clinical signs of CLS. This results in the development of noncardiogenic generalized edema including pleural effusion or ascites (or both) and instability of blood pressure, necessitates volume substitution, needs more inotropic support and may result in low cardiac output and death. So it is important to analyze the clinical course of postoperative CLS after cardiac operations.PART ONE: Clinical study of Capillary leak syndrome related to cardiopulmonary bypass in children underwent cardiac operationsFrom June, 2001 to December, 2001, 501 cases of congenital heart defects aged 7days to 108 months underwent cardiac operations. There are 135 cyanotic congenital heart defects (73.1%) and 366 acyanotic congenital heart defects (26.9%). 21 kinds of operations were carried out including total correction of Tetralogy of Fallot, VSD, ASD, the arterial Switch operation et al. 22 cases of congenital heart defects with CLS were identified in 501 cases of...