| Diabetes Mellitus (DM), a multi-etiopathogenisis metabolic disease, characterized with chronic hyperglycemia and metabolic disorder of sugar, fat and protein induced by the malfunction of insulin secretion or utilization. It is a worldwide serious health problem and can cause severe complications including kidney failure, acroisa, leg and foot damage, heart attack and stoke. T2DM, about 95% of DM, showes that not only organism has a resistance against insulin which is necessary for glucose metabolism but also beta cell of islet will suffer a certain damage. T2DM has a complex disease characteristics: the disease's development is affected by environmental factors and genetic factors. However, the pathogenesy is still not clear. Epidemiological investigation showed that T2DM is closely related with fat.,The activation of PPAR y mediated the express of proteins related to fat metabolism. PGC-1 regulate glyconeogenesis, β oxadation of fatty acid and cell differentiation of fat, which are all contacted with the effect of insulin signal pathway. From the study and research in the past, we consider that obesity...
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