| Background Estrogenic effects of persistent organochlorine contaminants, including polychlorinated biphenyls (PCBs), dichlorodiphenyltrichloroethane and hexachlorocyclohexane isomers (HCHs), have been testified by many in vitro or in vivo experiments. These contaminations could accumulate in environment and can exist for a long time, and they may increase the risk of estrogen-related diseases of human. The population health effects of daily exposure level of persistent opganochlorine contaminations have been focused on recently.Objective To study the body burden of organochlorine pesticides and residues of non-occupational exposure population; to study the relationship between foods and organochlorine pesticide level in serum; to study the relationship between human breast cancer and organochlorine contaminations exposure.Methods1. Cross-section study From Mar. 2004 to Jul. 2004, 107 men and 142 women, who were all health community residents, were investigated. The questionnaire mainly about food frequency of daily intake, and 2ml serum were collected at the same time. DDTs and HCHs serum level were detected by EC-ECD. Statistical analysis methods included liner regression and ridge regression.2. Meta analysis We collected 24 reports about breast cancer and organochlorine contaminations from 1990 to 2004. Meta analysis composed of three parts, the first, to estimate the synthesis standard difference of case group and control group, the second, to estimate the dose-response relation between organochlorine contaminations and breast cancer, the third, to estimate the high-exposure risk of organochlorine by M-H or D-L methods. The causes of heterogeneity were explored by sub-group analysis.3. Case-control study 102 breast cancer patients and 165 health women as control were investigated. Risk factors of breast cancer were collected by means of questionnaire. And CYP1A1/1B1 genotypes and organochlorine pesticide level in serum were measured in laboratory. We used logistic...
|
PDF Full Text Request