Studies On The Roles Of CTSD And MMP1 In Metastasis Of NPC Using RNAi

Nasopharyngeal carcinoma (NPC) is a special kind of malignant head and neck cancer with high incidence in Southeast Asia and Southern China. But its molecular mechanism is not very clear. Nowadays, Epstein-Barr virus (EBV), certain chemical carcinogens and genetic factors are thought to be closely associated with the pathogenesis of NPC.Metastasis of NPC is the main reason for the failure of treatment. However people know little about its molecular mechanism. Therefore, further selection and identification of the genes crucial for the metastatic dissemination is of great significance, not only for basic understanding of the molecular and cellular processes involved in NPC metastasis, but also for providing potential new therapeutic targets.Both of the 5-8F and 6-10B cell lines are originated from the SUNE-1 NPC cell line. Previous work has shown that the 5-8F cells are highly tumorigenic and metastatic while 6-10B cells just tumorigenic and nonmetastatic. Moreover, the microarray containing 8046 genes, produced by Shenzhen Chipscreen Biosciences Limited Co, was used to investigate the differentially expressed genes between...