Study On The Protective Effect Of Shengmai Injection And Thymopolypeptides On The Immunity Injuries After Cardiopulmonary Bypass

Objective: To study the protective effect and the mechanism of shengmai injection and thymopolypeptides on the immunological function injuries after cardiopulmonary bypass.Method: Sixty patients suffered from rheumatic heart valve disease were selected and divided randomly into three groups: control group (group C, n=20), shengmai injection group (group S, n=20), thymopolypeptides group (group T, n=20). Peripheral blood samples were taken three days before operation(T1), ten minutes after the termination of CPB(T2), on the first (T3), third (T4), and seventh (T5) day after operation respectively. Regular tests of the whole blood cells were executed. The percentage of T lymphocyte (TC) subsets including CD3 positive(CD3~+), CD4~+ and CD8~+TC as well as the ratio of CD4~+/CD8~+ TC were examined with flow cytometry. Immunoglobulin (Ig)G, Ig A, Ig M were measured with IMMAGE. Blood serum levels of interleukin-8 and interleukin-10 were assayed with enzyme-linked immunosorbent assay method.Result: Clinically, no mortality or major morbidity were observed. ?Compared with those of group C, counts of white blood cell and neutrophil were lower in group S at T2(P<0.01). In group S, the percentage of CD3~+ and CD4~+ TC was lower than those in group C at T4 and T5 respectively (P<0.05 or P<0.01) , and the percentage...