Study Of Late Cardiac Function Of Patients With Heart Failure After Marrow Stem Cells Transplantation

Objective:To study the effect of marrow stem cells transplantation on late heart function in patients with heart failure. Methods : From October 2003 to June 2004, we took 3 patients with dilated cardiomyopathy into group A, isolated and cultured marrow stem cells (MSCs)obtained from the 3 patients, then infused MSCs into ventricular myocardium through left and right coronary artery. On the other hand, we took 7 patients with severe bicuspid valve disease and heart failure into group B1, all these patients were treated with MSCs transplantation through left and right coronary artery and injecting into different parts of myocardium directly during the surgery of bicuspid valve replacement. Divided 10 patients treated in the last 2 years with severe bicuspid valve disease and heart failure into group B2, patients in Group B2 were only performed bicuspid valve replacement. After 4 and 8 weeks, ejection fraction (EF) and cardiac output(CO) were evaluated. Results:In group A and B1, there were significant improvement in CO,EF after MSCs transplantation(p<0.01), especially after 8 weeks. Compared with B2 group, B1 group also has an obvious improvement in heart function after MSCs transplantation (p<0.01), and in 8 weeks, this effect was more significant. Conclusion:MSCs transplantation can improve the late heart function of patients with heart failure, and it may be a new way for curing heart disease in last term stage.