A Study On Yan Huimin 's Academic Thought And Clinical Experience And The Treatment Of Children With Henoch - Schonlein Purpura Nephritis By Yangyin

Objective1. As a famous TCM pediatrics doctor, ProfessorHuimin Yan who engaged in traditional Chinese medicine for more than 40 years in Beijing, she has great achievements and clinical medical experiencein diagnostic, treat, teach and research. This paper comprehensively summarized academic thought and clinical experience of Yan, in order to transmit and future develop on traditional Chinese medicine pediatric clinical research and innovation.2.At the same time, base on academic thought and experience of Professor Huimin Yan, she is full of experience on treatmentwith children allergic purpura nephritis, the core academic thoughts is diagnosis and treat disease with deficiency from Qi and Yin type. Within a lot of allergic purpura nephritis cases, the academic value of professor Yan had been further verified very well. Methods1. The key method of Professor Huimin Yan, who hasover 40 years clinical experience on children allergic purpura nephritis summarized as follow:From the etiology and pathogenesis, syndrome differentiation, treatment characteristics, various ancient and modern theory summary of her academic point of view, and sort out and validateshe is good at clinical disease diagnose and treatment, a comprehensive summary on treatment characteristics and academic experience of her teachers.2. The clinical research on the application of academic thought of Professor Yan. On allergic purpura nephritis moved extension with duration> 1 month or more) clinical study was done, and further application of nourishing Yin and clearing stasis decoction in the treatment of children with deficiency of both Qi and Yin type allergic purpura nephritis prospective randomized controlled observation and to evaluate the clinical efficacy and effect on immune and other physical and chemical indicators, to further verify academic experience ofProfessor Yan, in clinical effectiveness, innovation. Results1. The academic experience of Professor Huimin Yan:She has rich clinical experience, once as a heir of Mr. Yunyuan Liu, who is the one of first group old Chinese medicine experts, apprentice, inheritance the academic thoughts of Mr. Yunyuan Liu, his academic thought the influence of far-reaching. For example for the external emotional disorders, especially in children with cough and phlegm disease treatment, the way of Mr.Yunyuan Liu, following rules of Zhongjing Zhang, giving prescriptions of addition and subtraction cut, distinctive features, the curative effect is remarkable. At the same time for internal diseases treatment, especially on stomach disease, are more affected by the old Mr. Pengfei Wang, he is good at prescription for the treatment of spleen and stomach, professor. Professor Yanlearn experience from the essence of Mr. Wang, the treatment of pediatric spleen disease, effective. In short, Yan learn widely from other’s strong points, and try to figure out the ancient predecessoracademic point of view, eclectic, adopt the advantage formacademic thought form others.Inthe clinic research, she payed attention to children’s physiological and pathological characteristics, especially on physical characteristics of contemporary children,treatment according to syndromedifferentiation, that means eight classic syndrome, syndrome and differentiation of Zang Fu organs as the core, emphasizing synthesis of the four diagnostic methods, especially children inspection, inheritance of Mr. Yunyuan Liu original infantile tongue observation method, and should be inherited and carried forward.Emphasis on the differentiation of disease, diagnosis and treatment based on disease differentiation, so as not to delay the illness. To observe the pathogenesis, dialectical medication to uphold the general principle, take into account the actual situation, tackling the problem. Both treatments of Spleen disease or for other exogenous or endogenous diseases treatment, support healthy are stressed by strengthening healthy the spleen and stomach as the center, taking into account his dirty.Eliminating evil for the amount of and a key link in the course of treatment, both inside and outside of the evil both, especially due to indigestion, damp heat, phlegm and blood stasis evil is emphasized. When will the classical prescriptions and the combination, flexible application, use light rigorous, good application of medicine.Reflected in the treatment of Infantile Spleen disease, Fuzheng Jianpi with nourishing the spleen and stomach, spleen to help transport; liver and spleen Tongzhi, adjustable Chang angry machine to congestion in the gas machine; utilize consumer guide to remove dyspeptic evil, tonification and purgation in combination; for Helicobacter pylori infection in children, pay attention to get rid of heat evil, attacked a degree; chronic illness on dispel stasis evil. In the treatment of pediatric pulmonary system disease, cough due to exopathy early, get rid of evil to avoid purging too; acute cough dispelling phlegm focuses on the treatment of pulmonary Qi regulating and chronic cough and asthma focusing on Fuzheng hilling gold, for children with recurrent cough syndrome, rousing lay different emphasis, staging and treatment, both samples, in order to promote the rehabilitation, prevent repeated. This paper also summarizes experience of ProfessorYan in treatment for children with a variety of diseases, such as chronic cough, bronchiolitis, anorexia, stomach pain (Helicobacter pylori associated gastritis) occlusion, lag Yee, lick sore, fetal yellow, glandular adenoid hypertrophy, chalazion, sty disease Pro bed experience summary and test case analysis.Professor Yan study diagnosis and treatment technology of modern medicine, the research on the combination of traditional Chinese and Western medicine to try, harvest quite good. Since 1989, the first in the country to carry out the work of pediatric gastroscopy, so far in order to carry out thousands of cases of pediatric gastroscopy. On the basis of gastroscopy, that is a useful attempt to explore the relationship between microscopic and macroscopic syndrome differentiation of gastrointestinal mucosa in children, and to observe the objective detection index of microscopic pathological changes. At the same time, clinical and scientific research, teaching, both inheritance and innovation development, in order to make pediatric career have qualified successors.The clinical research of Professor Yan in the diagnosis and treatment of children with allergic purpura nephritis:This paper focuses on the diagnosis and treatment of Professor Yan in children with allergic purpura nephritis. Think of Henoch Schonlein purpura nephritis is deficiency in Qi and Yin deficiency Syndrome Foundation, deficiency, blood stasis, together with damp heat. The treatment cycle is long, should be phased debate treatment, early to detoxifying, removing dampness, activating blood circulation to dissipate blood stasis mainly, along with the extension of the duration of the disease, with Qi and Yin deficiency is gradually emerging, with Qi and Yin deficiency, Yin deficiency and internal heat symptoms gradually increased. So the latter are prone to yin deficiency, Qi deficiency symptoms, and there is still clip blood stasis wet like, supplementing Qi and nourishing Yin and strengthening the spleen and fine and Qing Huayu Tongluo. According to children in different stages of the main contradiction of Chinese medicine according to syndrome differentiation, the trial due to differentiation of symptoms and signs, in traditional Chinese medicine for sequential treatment of diseases of thinking, rousing, specimens Tongzhi principles throughout the treatment.In view of Henoch Schonlein purpura nephritis deferment of children, to Yin deficiency syndrome in children with more, and previous studies are relatively uncommon situation,116 cases of duration of greater than 1 month or more of allergic purpura nephritis in children, for three types of the type of deficiency of both Qi and Yin, hot and humid stasis and internal heat due to yin deficiency syndrome is divided into observation. Using IBM SPSS statistics 21 software for data statistical calculation and analysis, the statistical calculations were performed using the non parametric test, with the type of deficiency of both Qi and Yin most 72 cases,62.07%; damp heat and blood stasis type 33 cases accounted for 28.4%; 11 cases of internal heat due to yin deficiency, 9.48%. The physical and chemical indicators of detection. The results suggest that there is some correlation between the degree of hematuria and proteinuria, and the disorder of humoral immunity, cellular immunity, coagulation and fibrinolytic system in children with type three. T cell subsets and coagulation index D-D may have some correlation with clinical syndromes.In deficiency of both Qi and Yin children have included 66 patients (mild hematuria and proteinuria type selection, without the use of immunosuppressive therapy),Professor Yanapplication proposed Qing Yu Tang, and fosinopril and control, randomized, prospective study, every 4 weeks for monitoring blood routine, urine routine, examination of the liver and kidney function and electrocardiogram (ECG),24 hour urinary protein, blood coagulation, complement C3, C4, immunoglobulin (Ig) series, T cell subtypes, records of the traditional Chinese medicine syndrome and semi quantitative score observed syndromes of traditional Chinese medicine, clinical efficacy and physical index of the change. According to the data, the statistical methods such as chi square test, t test, and repeated measures ANOVA analysis were used.The results showed that the improvement of TCM syndrome in the treatment group was significantly better than that in the control group. TCM group treatment of 4 weeks, the total efficiency of 91.18%,8 weeks in total efficiency is 97.06%; western medicine group 4 weeks, the total efficiency was 71.88%,8 weeks, the total effective rate was 87.5%, in improving the deficiency of both Qi and Yin, blood stasis and dampness symptoms, traditional Chinese medicine has a larger advantage. For mild proteinuria (<25mg/kg · d) treatment, pure Chinese medicine therapy and simple western medicine are more effective, and the curative effect is very different. In the treatment of hematuria, Chinese medicine treatment more advantages. On the improvement of immune index, the IgA values of 4 weeks and 8 weeks after treatment were compared betweentwo groups, the difference was statistically significant, and the Chinese medicine treatment group was significantly lower than that in the IgA. It is suggested that compared with western medicine treatment, Chinese medicine for improving the role of T helper cell CD4+is more obvious. Meanwhile, the improvement of the traditional Chinese medicine treatment of the complement system may be more effective. In the first 4 weeks of treatment, the effect of Chinese medicine on reducing D-D value was more obvious than that of Western medicine. Traditional Chinese medicine may use a shorter time to adjust the body’s blood coagulation mechanism, improve fibrinolytic system. ConclusionsWith academic experience and method of traditional Chinese medicine of professor Yan, supplementing Qi and nourishing Yin, clearing heat and activating blood circulation to remove blood stasis, rousing, type of deficiency of both Qi and Yin in the treatment of allergic purpura nephritis in children, compared to western medicine observation group, can effectively alleviate the syndromes of traditional Chinese medicine, the more effectively reduce hematuria, proteinuria, immune, improve the coagulation mechanism.