Studies On The Expression Pattern And Possible Roles Of Centrosomal Proteins, The Centrin And Cenexin, In Rat Spermatogenesis

The centrosome is a cytoplasmic organelle consisting of a pair of centrioles and the pericentriolar material that serves as an organizer for the assembly of cellular microtubule, mitotic spindle and astral, and in some animal cells it associated with the initiation of cilia, flagella and thereby the overall polarity of a cell. It has been documented that more than 30 centrosomal proteins have been identified. Among them, the gamma-tubulin and centrins are considered to be the two main kinds of centrosomal proteins, while cenexin was identified as a marker molecule of the mature centriole. However, the detailed knowledge on the centriolar structure and functions in germ cell, especially the molecular mechanism and the role of centrosomal proteins on spermatogenesis and spermiogenesis is still quite limited, for instance, whether germ cell centrioles possess new peculiar proteins that regulate meiosis of spermatocytes? What functions do they perform in the initiation and organizing of the sperm flagellum? What signals stimuli for the migration of...