| Purpose:In this paper,elderly rheumatoid arthritis(RA)patients hospitalized in the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from October 2020 to September 2022 were selected to explore the symptom distribution characteristics and medication rules of elderly rheumatoid arthritis patients by retrospective analysis.Provide more experience for TCM differentiation of elderly RA.Method:Based on the inpatients in the Department of Rheumatology and Immunology,the Department of Rheumatology Rehabilitation,and the Classical Ward of Internal Medicine(formerly the Department of Cardiopulmonary Rehabilitation)of the Affiliated Hospital of Liaoning University of Chinese Medicine,the case data were screened in accordance with the inclusion and exclusion criteria,the matching case data was collected and sorted into Excel,and Microsoft Excel 2016,SPSS 22.0and SPSS Modeler 18.0 were used to analyze frequency statistics,clustering and association rules,and the results were discussed.The distribution characteristics of symptoms and medication rules of elderly rheumatoid arthritis were analyzed.Results:1.general information: 202 cases were eventually screened.There were 40 male patients(19.80%)and 162 female patients(80.20%),and the male to female sex ratio was 1:4.05.The mean age was 69.668±7.003 years.2.Distribution of TCM syndromes: Among the 202 cases included in the statistics,in descending order according to the frequency of occurrence,there were cold and dampness obstruction,cold and dampness obstruction combined with blood stasis,phlegm and blood stasis obstruction,dampness and heat obstruction combined with blood stasis,dampness and heat obstruction combined with Qi and Yin deficiency,Qi and Yin deficiency combined with blood stasis,deficiency of liver and kidney,deficiency of liver and kidney,qi and blood deficiency.Positive evidence(cold dampness obstruction syndrome,phlegm-stasis obstruction syndrome,dampness-heat obstruction syndrome,cold dampness obstruction combined with blood stasis syndrome and dampness-heat obstruction syndrome)> deficiency syndrome(deficiency of liver and kidney,deficiency of Qi and Yin and deficiency of qi and blood)> deficiency syndrome of deficiency of deficiency of qi and Yin and deficiency of blood stasis syndrome)> deficiency syndrome of deficiency of deficiency of qi and Yin and deficiency of liver and kidney and blood stasis syndrome).There were 77 cases with blood stasis in all the syndromes,accounting for 38.11%.3.Medication: a total of 165 flavors of traditional Chinese medicine are involved,the frequency of medication is a total of 1874 times,the highest frequency of medication is 84 times,the lowest is 1 time,the number of Chinese medicines ≥ 35 has 15 flavors,their cumulative frequency is 44.08%,which is a common drug for the clinical treatment of RA in the elderly,in order: angelica,licorice,Chuanxiong,oxknee,white peony,astragalus,poria,baishu,solitude,qianghuo,red peony,chicken blood vine,mulberry parasitism,eucommia,raw ground yellow.The 165 traditional Chinese medicines collected were divided into 16 categories according to their efficacy.Among them,the frequency of tonic medicine was 29.40%,followed by rheumatism medicine was 14.67%,blood activating and blood stasis removing medicine was14.14%,heat clearing medicine was 11.69%,antidote medicine was 8.43%,and the frequency of other types of drugs was low,with a cumulative value of less than 25%.Systematic cluster analysis divides traditional Chinese medicines into 7 categories:Class 1: Atractylodes,Atractylodes,Honeysuckle,Poria cocos;Class 2: Cinnamon branch,Chuanwu,Qianghuo,Mulberry branch;Class 3: Red peony;Class 4:Astragalus,Atractylodes;Class 5: Angelica,Chuanxiong,Poria;Class 6: Rehmannia,Chicken Blood Vine,Mulberry Parasite,Asarum,Eucommia ulmoides,Rehmannia,Duhuo,Codonopsis;Class 7: Baishao,Achyranthes,Licorice.A total of 117 association groups were obtained in the association analysis,and among all the association rules,(1)when the previous item is 1: the support of angelica + poria is the highest 44%.(2)When the previous item is 2: the support of Chuanxiong +Oxknee + Angelica is the highest 43.20%.(3)When the previous item is 3: the support of Chuanxiong + Pori + Licorice + Angelica is the highest 33.60%.Conclusions:1.The majority of elderly RA patients were empirical,followed by deficiency syndrome,and least mixed syndrome.The most common type of syndrome is cold and dampness obstruction.There is no evidence of deficiency and deficiency,and both have the syndrome of blood stasis.2.Clinical drugs used in elderly patients with RA are mainly dispelling pathogenic factors,and supporting normal body is supplemented,among which tonifying deficiency drugs,dispelling wind and dampness drugs,clearing heat drugs and relieving surface drugs are the most used.3.The high frequency Chinese medicines of aged RA were angelica sinensis,licorice,ligusticum Chuanxiong,Rhizoma bidentata,Radix paeoniae alba,Radix Astragalus,poria cocos,Radix atractylodes alba,Radix singularia,Radix Qiangli,Radix Paeoniae alba,Radix spatholobi,mulberry parasitica,Eucommia ulmoides and Radix rehmanniae.4.Cluster analysis was performed on 25 herbs with the number of administration ≥25,and the herbs were divided into the following categories: Class 1: atractylodes atractylodes,Thiodioscorea septemba,poria cocos and honeysuckle;Class 2: cassia branch,Sichuan aconite,Qiang live,mulberry branch;Class 3: Red Peony root;Class4: Astragalus and Atractylodes;Class 5: Angelica sinensis,Ligusticum Chuanxiong,poria cocos;Class 6: Cooked Rehmannia,subspatholobi,mulberry parasitic,asarum,Eucommia ulmoides,raw Rehmannia,live alone,codonopsis;Class 7: Paeony,achyranthes alba,licorice。... |
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