Study On The Distribution Characteristics And Medication Rules Of TCM Syndrome Types In Acute Gouty Arthriti

Purpose: A retrospective analysis was used to investigate the distribution characteristics of TCM evidence patterns in acute gouty arthritis(AGA)and to explore the patterns of drug use,in order to provide more references and references for TCM evidence-based treatment.Material and method : The rheumatology and rheumatology rehabilitation departments of the Affiliated Hospital of Liaoning University of Chinese Medicine from October 2019 to September 2021 were used as the data source,and the cases were screened in strict compliance with the inclusion and exclusion criteria.105 eligible cases were selected(each patient records the composition of his or her first prescribed medication,that is,"one person,one prescription."),and the data were analyzed using Excel frequency statistics,SPSS 26.0 cluster analysis and SPSS Modeler 14.2 association rule Apriori The data were mined for medication experience using methods such as Excel frequency statistics,SPSS 26 0cluster analysis and SPSS Modeler 14.2 Apriori.We analyzed the distribution characteristics of TCM evidence patterns of acute gouty arthritis,as well as the correlation of related factors,and explored the pattern of medication use.Results:1.A total of 105 valid cases were collected in this study,including 96 males and 9 females,with a male-to-female ratio of 10.67:1;the average age was 42.08±14.13 years,with 21-60 years being the high incidence age group,and 67.62% of the patients were first-episode patients.2.Distribution of evidence types(in descending order of percentage): 60 cases(57.14%)with damp-heat evidence > 21 cases(20.00%)with cold-heat evidence > 13 cases(12.38%)with heat-stasis evidence > 6 cases(5.71%)with phlegm-stagnation evidence > 5 cases(4.76%)with liver-kidney deficiency evidence,with mainly solid evidence and few deficiency evidence.3.In this study,105 prescriptions were collected,involving 116 Chinese medicines,with a total frequency of 1338 times and 15 drug categories.Heat-clearing drugs,water-releasing and damp-permeating drugs,deficiency-supplementing drugs,table-relieving drugs and blood-stasis-activating drugs were the main drug categories for the treatment of this disease.Atractylodes macrocephala,Atractylodes bidentata,Coix lacrymae.The 38 kinds of Chinese medicines with the frequency of use >10,such as Phellodendron,are commonly used in the treatment of acute gouty arthritis,and their medicinal properties are mainly cold,and their taste is mainly sweet,bitter and pungent,and their meridians are mainly the spleen,lung,stomach,liver and kidney meridians.The 38 herbal medicines used for more than 10 times were clustered and analyzed,and eight clusters were obtained: category 1: Atractylodes macrocephala,Phellodendron,Achyranthes bidentata,Coix lacryma;category 2: Slippery Rock,Almond,Antibiotics,Pueraria lobata,Paeonia lactiflora,Gypsum;category 3: Cinnamomum cassiae,Radix et Rhizoma,Fructus Anemarrhenae,Ephedra,Zhi Mu,Paeonia lactiflora,Ginger;category 4: Radix Angelicae Sinensis,Peach kernel,Atractylodes macrocephala,Atractylodes brandii,Zedoary,Yam,Cinnamon,Plantago,Rhizoma Dioscorea,Rhizoma Dioscorea,Money Plant,Rhizoma Polygonatum,Rhizoma spp.Rhizoma Dioscorea,Money Grass,Cornu Cervi Pantotrichum,Chen Pi;Category 5: Scutellaria baicalensis,Semen,Huang Lian,Radix Codonopsis pilosulae,Ginger,Jujube;Category 6: Fu Ling;Category 7: Poria cocos;Category 8: Licorice.We derived the common formulas such as Si Miao San,Plus and Minus Mu Fang Ji Tang,and Gui Zhi and Peony Zhi Mu Tang.5.Association analysis was performed,and 126 association rules for drug pairs and drug groups were obtained after setting the drug use rules,and the commonly used drug pairs were Atractylodes macrocephala,Atractylodes nux vomica,Phellodendron,Atractylodes nux vomica,Coix seed,Atractylodes nux vomica,Phellodendron,Atractylodes nux vomica,etc.,which are the basic components of the famous formula Si Miao San.Among them,the highest support was 72.38% for Atractylodes macrocephala and Atractylodes nux vomica.Conclusion:1.The pathology of acute gouty arthritis is mainly evil and real;the distribution of evidence types is mainly damp-heat accumulation evidence.2.The study showed that the most common types of drugs are heat-clearing drugs;the most commonly used drugs are mainly cold,with the most sweet,bitter and pungent flavors,and the most spleen meridians.3.High-frequency drugs include Atractylodes macrocephala,Atractylodes nux vomica,Coix seed,Phellodendron cypress,and Tu Fu Ling,etc.;the highest support of commonly used drugs is Atractylodes nux vomica and Atractylodes nux vomica.Si Miao San,Plus and Minus Mu Fang Ji Tang,and Gui Zhi and Peony Zhi Mu Tang are commonly used formulas.