Observation On The Clinical Efficacy Of Tongfeng No. 2 Prescription In The Treatment Of Acute Attack Of Gouty Arthritis (damp-heat Accumulation Syndrome

Objective: This study was intended to evaluate the clinical efficacy and safety of Gout No.2 prescription by observing the effects of gout No.2 prescription on the symptoms,signs and laboratory indexes in the acute phase of gouty arthritis.It provides a more effective,simple and feasible treatment method for the clinical treatment of damp-heat accumulated gouty arthritis,and brings better therapeutic effect for patients.Methods: A total of 66 gouty arthritis patients who met the diagnostic criteria and belonged to damp-heat congeners and were willing to participate in this study were selected from Changde First Hospital of Traditional Chinese Medicine from January 2022 to February 2023.They were randomly divided into Gout No.2prescription combined with etecaoxi pian group(treatment group)and etecaoxi pian group(control group)by using the method of random number table,with 33 cases in each group.The control group was given etopoxipian 120 mg once a day for1 week.On the basis of taking western medicine,the treatment group took Chinese medicine orally twice a day in the morning and evening for 1 week.After the course of treatment,VAS score,symptom score,blood uric acid,erythrocyte sedimentation rate and C-reactive protein were analyzed scientifically to evaluate the clinical effect of Tongfeng-2 formula.Results: There were no significant differences in age,gender,course of disease,VAS score before treatment and scores of symptoms between the two groups(P >0.05),indicating that the data between the two groups were comparable.After 1week of treatment,blood uric acid,erythrocyte sedimentation rate and C-reactive protein in 2 groups were lower than before treatment(P < 0.05),and the treatment group was better than the control group(P < 0.05).After 1 week of treatment,VAS scores in both groups were lower than before treatment(P < 0.05),and the treatment group was better than the control group.After 1 week of treatment,the scores of tenderness,swelling and limited movement in both groups were lower than those before treatment(P < 0.05),and the treatment group was better than the control group in improving symptoms of swelling and limited movement(P < 0.05).The two groups were equally effective in improving the symptoms of tenderness(P> 0.05).There was no significant difference in clinical efficacy between the two groups after treatment(P > 0.05),indicating that the two groups had similar clinical efficacy.In terms of safety,no obvious adverse reactions occurred in both groups,indicating that the test was safe.Conclusion: This study showed that Gout No.2 prescription combined with etecoxi was effective in treating gouty arthritis in the acute phase(damp-heat syndrome),and could effectively reduce the level of uric acid,CRP,ESR and other inflammatory indicators and improve clinical symptoms.Compared with oral etocoxib alone,the clinical efficacy and safety of the two drugs are comparable,and the former is better in reducing uric acid level,reducing inflammatory indicators such as CRP and ESR,and improving patients’ related clinical symptoms.